Research advances in understanding the role and mechanism of pyroptosis in myocardial ischemia-reperfusion injury
Journal Title: Perioperative Precision Medicine - Year 2024, Vol 2, Issue 2
Abstract
Myocardial ischemia-reperfusion injury (MIRI) emerges when the restoration of blood flow fails to recover myocardial function following transient ischemia, marking a significant pathological challenge that adversely affects revascularization outcomes and patient mortality. This condition often occurs post-cardiac procedures, including cardiopulmonary bypass, angioplasty, primary percutaneous coronary intervention, and thrombolytic therapy. Over the last decade, researches have been pivotal in deciphering the pathophysiological underpinnings of MIRI, aiming to identify viable targets and therapeutics for mitigation. Among these, pyroptosis, a form of inflammatory, programmed cell death, has been recognized for its integral role in MIRI, interacting with various other mechanisms such as oxidative stress, calcium dysregulation, autophagy, ferroptosis, and apoptosis. This review delves into the mechanisms by which pyroptosis influences MIRI, discusses its impact on both cardiomyocytes and non-cardiomyocytes in MIRI, and highlights recent advancements in the development of inhibitors targeting key molecules involved in pyroptosis such as Nod-like receptor protein 3 inhibitors, Caspase-1 inhibitors, and traditional Chinese medicines.
Authors and Affiliations
Ziyue Li, Bailong Hu, Xiaohua Zou
Keywords
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- EP ID EP749977
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