Research progress of oxidative stress in sepsis-associated liver injury

Journal Title: Perioperative Precision Medicine - Year 2024, Vol 2, Issue 1

Abstract

Sepsis is a systemic inflammatory response that caused by infection or trauma, often resulting in multiple organ dysfunction. Its mortality rate is relatively high, ranging between 54% and 68%, and ineffective treatment and poor prognosis pose significant challenges to healthcare in recent years. One of the main pathogeneses of sepsis-induced liver injury is oxidative stress (OS), which refers to a state where the antioxidant system cannot balance oxidative products, leading to the accumulation of excessive oxidative products in the body. When sepsis occurs, the amount of reactive oxygen species produced by the body increases far beyond the levels that can be scavenged by the antioxidant system, thus damaging liver cells and aggravating liver damage. This article introduces the oxidative/antioxidant system, oxidative stress-related pathways, and the molecular mechanism of OS in various types of hepatocytes, with emphasis on the antioxidant treatment on different hepatocytes, in order to understand the mechanism of OS involved in the development and progression of sepsis-associated liver injury. As the research deepens, improving liver function through the treatment of different cells and facilitating related clinical research are expected to provide a new target pathway for the treatment of sepsis-associated liver injury.

Authors and Affiliations

Hui Su,Tianying Xu, Renke Sun, Yu Xiang, Yangmengna Gao, Kecheng Zai, Shangping Fang

Keywords

Related Articles

Research progress of frontier image processing in medical endoscopes

In the modern medical diagnosis, digital medical images can provide physicians with a more accurate, visualized, and three-dimensional view of various tissues. These images assist in predicting, diagnosing, and treating...

Progress of ultrasound-guided nerve block in foot and ankle arthroscopy

Foot and ankle arthroscopy frequently results in severe perioperative swelling and pain. The ultrasound-guided nerve block technique stands out for its ability to offer reliable and potent pain relief. This technique not...

Research progress of oxidative stress in sepsis-associated liver injury

Sepsis is a systemic inflammatory response that caused by infection or trauma, often resulting in multiple organ dysfunction. Its mortality rate is relatively high, ranging between 54% and 68%, and ineffective treatment...

The interaction of Candida albicans with C-type lectin receptors

Candida albicans (C. albicans) is a ubiquitous commensal in the mammalian flora and the most prevalent fungal pathogen of humans. As an opportunistic fungus, C. albicans can cause mucosal and invasive infections. Invasiv...

Thyroid disease-related sleep disorders and its diagnostic and therapeutic recommendations: A literature review

As perioperative medicine evolves, more hospitals are offering comfort sleep clinics. Thyroid disorders (e.g., hypothyroidism, hyperthyroidism, and thyroid cancer) affect the peripheral circadian clock. Elevated serum th...

Download PDF file
  • EP ID EP749972
  • DOI 10.61189/270899wnwlnz
  • Views 29
  • Downloads 0

How To Cite

Hui Su, Tianying Xu, Renke Sun, Yu Xiang, Yangmengna Gao, Kecheng Zai, Shangping Fang (2024). Research progress of oxidative stress in sepsis-associated liver injury. Perioperative Precision Medicine, 2(1), -. https://europub.co.uk/articles/-A-749972