The Interactive Roles of Some Toxic Metals, Micronutrients, Antioxidant Vitamin and Sex Hormones in Nigerians with Sickle Cell Disease
Journal Title: Journal of Advances in Medicine and Medical Research - Year 2016, Vol 12, Issue 12
Abstract
Aims: To define the involvement of sex hormones-estradiol, testosterone, toxic metals and micronutrients in individuals with sickle cell disease (SCD). Study Design: A case control study. Place and Duration of Study: Departments of Chemical Pathology and Haematology, College of Medicine, University of Ibadan, Ibadan, Haematology Outpatient Clinic, Ring Road State Hospital, Oyo State, Nigeria between Dec 2007 and Jul 2008. Methodology: One hundred and twenty participants, consisting of 68 with Haemoglobin S (SCD) and 52 with Haemoglobin A aged 17-43 years were recruited for the study. Five ml blood samples were obtained from each participant. Anthropometry and reproductive history were obtained by standard methods. Serum estradiol and testosterone concentrations were estimated using enzyme linked-immunoassay methods, Zinc, Copper, Selenium, Lead and Cadmium by atomic absorption spectrophotometry and vitamin E by High Performance Liquid Chromatography. Results: The mean Zinc, Copper, Vitamin E concentrations in SCD were significantly lower, while those of lead and Cadmium were significantly higher when compared with the corresponding control values (P <.001). The mean testosterone in male and estradiol in female (SCD) were significantly lower than the corresponding control values (P <.03). The mean age at menarche in SCD was significantly higher than the value in control participants. In female SCD, the serum estradiol was positively correlated with height and negatively correlated with lead in the control (P =.05). The incidence of priapism in male SCD was significantly higher than the value in male control subjects (P <.007). In both male and female SCD, the mean body mass index and body weight were significantly lower than the corresponding values in the control group (P <.006). Conclusion: A significant number of Nigerians with SCD had priapism and the observed oxidative stress in SCD probably due to hypogonadism, may be amenable to micronutrient supplementation.
Authors and Affiliations
Funmilola Comfort Oladele, Mabel Ayebatonyo Charles-Davies, Titilola Stella Akingbola, Francis Adebayo Adeniyi
Keywords
Related Articles
- EP ID EP340488
- DOI 10.9734/BJMMR/2016/22587
- Views 57
- Downloads 0
ARMS-PCR Based SNP Analysis of MTHFR C677T Allele Using Syber Green in Pancreatic Tumour
In human, carcinoma of pancreas, a rare disease and mortality rate is quite high in Indian population. Epidemiological studies support the hypothesis that folate metabolism regulate DNA stability and prevent cancer. Beca...
Ex vivo Analysis of Three Electronic Apex Locators Accuracy with Different Settings
Aims: The correct determination of a root canal length is a fundamental step for an adequate chemical-mechanical preparation and consequently, for a successful endodontic treatment. Electronic apex locators (EAL) were de...
Assessment of Oral Health Knowledge, Attitude and Practices among Medical Students of Taibah University in Madinah, KSA
Introduction: Oral health is as important as any part of the body and can greatly influence the human beings' normal life and well-being. Better oral health can be achieved with increased awareness and proper oral health...
Correlation of Platelet Distribution Width [PDW], Mean Platelet Volume [MPV] and Red Cell Distribution Width [RDW] with Serum Blood Sugar Levels: A Case- control Study in the West Luck Now Population
Background: Diabetes itself is known to have long standing complications of both micro-vascular as well as macro vascular type. One of the life threatening complications that diabetes gives rise to is stroke and Ischemic...
Analysis of Undergraduate Students’ Perception of the Educational Environment of a Medical School in Zambia Provided a Framework for Strategic Planning
Aim: To propose a strategy for improvement of undergraduate students’ learning environment based on analysis of their perceptions. Methods: Medical, Pharmacy, and Physiotherapy undergraduate students participated in the...