The intraocular pressure changes following intravitreal bevacizumab injections in an Indian population
Journal Title: Indian Journal of Clinical and Experimental Ophthalmology - Year 2018, Vol 4, Issue 1
Abstract
Aimnbsp To assess the changes in Intraocular pressure IOP after intravitreal bevacizumab therapyDesign Prospective Observational Tertiary care hospital based studyParticipants 95 patients receiving intravitreal bevacizumab for varying indications were includedMaterials and Methods A study of the change in intraocular pressure of 95 patient eyes receiving intravitreal injection of bevacizumab for varying indications was performed at 4hours 2 weeks and 6 weeks post injectionResults There was a statistically significant increase in IOP 4 hours post injection p value 000 95 confidence limits of 207 to 111 mean difference of 159 There was no statistical significance in IOP rise at 2 weeks p 032 95 confidence limits of 113 and 018 mean difference of 047 or at 6 weeks p 100 95 confidence limits of 086 to 044 mean difference of 021 The endpoint IOP in the single injection and multiple injection groups was statistically insignificant t032 df 92 significance value0749 95 confidence interval 148 to 107Conclusion Although a statistically significant shortterm rise in IOP was observed this increase was clinically insignificant The IOP reverted towards baseline values on subsequent visits at 2 weeks and 6 weeks postinjection The number of injections did not have any effect on the IOP changeClinical significance Our study evaluated the effect of intravitreal injection of bevacizumab on intraocular pressure in an Indian population and found no clinically significant rise in the sameKeywords Bevacizumab Intraocular pressure VEGFA
Authors and Affiliations
Yogish S. Kamath, Ashish Rander, Shailaja B S, Lavanya G. Rao, Sulatha V Bhandary
Keywords
Related Articles
- EP ID EP474196
- DOI 10.18231/2395-1451.2018.0020
- Views 83
- Downloads 0
Study of rise of IOP and visual acuity after ND YAG laser capsulotomy in patients with posterior capsular opacification
Aims: To assess the 1. rise of IOP without use of pre procedure and post procedure anti glaucoma medication 2. and to note the improvement in visual acuity. 3. to...
Pattern of Glaucoma in Rural South India
Introduction: Primary Open Angle Glaucoma causes damage to the fibers of optic nerve which results in permanent visual loss. There may not be any symptoms; this is dangerous because patient may become blind silently. Gla...
Statistical Errors in Ophthalmic Research
“Biomedical statistics is essential part of any scientific study; a review of the current scientific literature indicates that statistical analysis is an area that frequently needs improvement. To address this, we put fo...
A four year retrospective & prospective study of ophthalmia neonatorum
Introduction: Ophthalmia neonatorum is one of the most common infections occurring in the first month of life. 1 Neonatal ocular infections have been largely associated with various poor perinatal outcomes. The purpose o...
Evaluation of corneal endothelial cell changes in diabetic patients before and after phacoemulsification surgery: A comparative study
Aim The study was conducted to evaluate and compare the changes in corneal endothelial cell count density ECD and Central corneal thickness CCT between diabetic and non diabetic population before and after phacoemulsific...