The Mechanism of Single Progesterone as Add-Back Therapy to GnRH-a Administration
Journal Title: World Journal of Gynecology & Womens Health (WJGWH) - Year 2019, Vol 1, Issue 5
Abstract
Endometriosis (EMS) is a common estrogen-dependent gynecological disorder, which affects quality of life and fertility of productive-aged women [1]. Current treatment of EMS is mainly based on surgery and post-operative maintenance treatment of ovarian suppressive agents. A major challenge for women with EMS is the post-operative recurrence [2-3]. Some medical treatments have been suggested for EMS, such as oral contraceptive pills, and gonadotropin-releasing hormone agonists (GnRH-a). GnRH-a is an important treatment modality for EMS, significantly reducing EMS-related symptoms [4-6]. However, the employment of GnRH-a could reduce the estrogen level, leading to severe peri-menopausal symptoms such as hot flash, colpoxerosis, sexual hypoactivity, and bone loss, which hinders its long-term and extensive application [7]. The peri-menopausal symptoms could be solved by the hormone based “add-back therapy” [8-10]. As for add-back therapy, three regimens were recommended by Obstetrics and Gynecology Branch of Chinese Medical Association [11].
Authors and Affiliations
Ruxia Shi
Keywords
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- EP ID EP609288
- DOI 10.33552/WJGWH.2019.01.000521
- Views 95
- Downloads 0
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