The omega-3 and retinopathy of prematurity relationship
Journal Title: International Journal of Ophthalmology - Year 2017, Vol 10, Issue 2
Abstract
The aim of this article is to examine the effect of omega-3 (ω-3) long-chain polyunsaturated fatty acids (LCPUFAs) intake on retinopathy of prematurity (ROP) by reviewing the experimental and clinical trials conducted on animal models and infants. LCPUFAs demonstrate cytoprotective and cytotherapeutic actions contributing to a number of anti-angiogenic and neuroprotective mechanisms within the retina. Their intake appears to have a beneficial effect on ischemia, oxidative stress, inflammation and cellular signaling mechanisms, influencing retinal cell gene expression and cellular differentiation. ω-3 LCPUFAs may modulate metabolic processes that activate molecules implicated in the pathogenesis of vasoproliferative and neurodegenerative retinal diseases such as ROP.
Authors and Affiliations
Asimina Mataftsi
Keywords
Related Articles
- EP ID EP610797
- DOI 10.18240/ijo.2017.02.19
- Views 50
- Downloads 0
Adenocarcinoma of the nonpigmented ciliary epithelium manifested as an anterior chamber mass
Letter
Comparison of the impact of epigallocatechin gallate and ellagic acid in an experimental cataract model induced by sodium selenite
"AIM: To compare the potential protective effects of epi-gallocatechin gallate (EGCG) and ellagic acid (EA) in an experimental cataract model. METHODS: Twenty-eight Spraque-Dawley rat pups were assigned into four groups....
Chronic photodamage in the chicken retina using 650-nm semiconductor laser
"AIM: To investigate the occurrence of chronic photodamage in the cone-based retina, following long-term exposure to a 650-nm semiconductor laser (power: 2 mW). METHODS: Chickens fed for 1mo under natural light after hat...
Effect on proliferation and apoptosis of retinoblastoma cell by RNA inhibiting high mobility group protein box-1 expression
"AIM: To investigate the effect of high mobility group protein box-1 (HMGB1) siRNA on proliferation and apoptosis of retinoblastoma (Rb) cells. METHODS: The expression of HMGB1 in Rb cells were detected by real-time poly...
A new diagnostic model of primary open angle glaucoma based on FD-OCT parameters
"AIM: To build a clinical diagnostic model of primary open angle glaucoma (POAG) using the normal probability chart of frequency-domain optical coherence tomography (FD-OCT). METHODS: This is a cross-sectional study. Tot...