The peculiarities of some gastroenterological diseases in elderly patients
Journal Title: Сучасна гастроентерологія - Year 2019, Vol 0, Issue 4
Abstract
The data presented in the paper were based on the recent investigations and currentrecommendations. The pathological changes in the gastroenterological profile are proved to be most prevalent in subjects aged 65 years and older. In this category of patients, the disorders may be mild or atypical, resulting in the late diagnosis and delays in the administration of timely treatment. Besides dysphagia and odynophagia, the most prevalent diseases of elderly patients are gastroesophageal reflux disease (GERD), Barrett’s esophagus and medicated esophagitis. With aging, the chronic atrophic gastritis and lethality due to complications of peptic ulcer become mostly prevalent. The particular attention has been paid to the fact that many elderly people are forced to use non-steroidal anti-inflammatory drugs (NSAID), antiplatelet or anticoagulant drugs due to comorbidities, which creates the need for an individual approach to the risks and rational approach to the prolongation of antipyretics’ administration. NSAID-induced gastropathy is a frequent cause of increased mortality from bleeding from the upper gastrointestinal tract. The pantoprazole administration is advisable for the effective treatment of GERD, chronic atrophic gastritis, NSAID-induced gastropathy justified. Domestic trials provided evidence for the efficacy and safety of «Zolopent» in this category of patients, which demonstrates a number of advantages over other proton pump inhibitors: longer acid-suppressing effect, higher pH selectivity and low levels of interaction with other drugs, treatment of patients with multimorbidity and polypharmacy. With aging liver is being affected as well. Alcoholic liver injury with cholestasis syndrome and drug-induced hepatitis are increasingly prevail. The rate of cholestatic liver injuries significantly increases with age. Ursodeoxycholic acid (UDCA) has an unconditional advantage in the treatment. The advisability of its use in elderly patients with cholestasis syndrome, due to anticholestatic and cytoprotective effects, as well as in the presence of biliary reflux, has been substantiated. The use of the domestic drug «Ukrliv» is justified in terms of pharmacoeconomic benefits and therapeutic efficacy.
Authors and Affiliations
O. V. Kolesnikova, A. O. Radchenko
Keywords
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- EP ID EP670115
- DOI 10.30978/MG-2019-4-23
- Views 112
- Downloads 0
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