The problem of Pseudomonas aeruginosa antibiotic-resistance and search of effective means of fighting
Journal Title: Бюлетень "Ветеринарна біотехнологія" - Year 2018, Vol 32, Issue
Abstract
Introduction. Pseudomonas aeruginosa (P. aeruginosa) is one of the “traditional” pathogens of purulent-septic diseases and complications, which causes about 30–70% of nosocomial infection cases. The causative agent has many pathogenicity factors and a complex of mechanisms for the development of resistance to antibiotics. P. аeruginosa is a pathogen for humans, animals and plants. Pseudomonosis is an acute contagious infectious disease of agricultural animals, fur animals, pets, birds, foxes, arctic foxes and fish. P. aeruginosa causes an infectious disease of young animals in the form of septicemia, toxemia with high mortality, and embryos death mainly in the last days of incubation. In adult animals Pseudomonas infection is characterized by the development of septicemia, pneumonia, encephalitis, aerosaculate, conjunctivitis, necrotic dermatitis, arthritis, hepatitis. The disease causes significant economic losses in livestock and poultry. The goal of the work was to study antibiotic resistance of P. aeruginosa in humane and veterinary medicine and research the effectiveness of the proposed anti–bacterial preparation Saroflox towards to P. aeruginosa. Materials and methods. Sensitivity of P. aeruginosa isolates to antibacterial preparations was determined by diffusion method in agar. The effectiveness of the proposed experimental antibiotic “Saroflox” against the isolates of P. aeruginosa was determined by the method of serial dilutions in a liquid nutrient medium – meat-pumped broth in comparison with enrofloxacin. Results of research and discussion. The presence of P. aeruginosa in the smears from the objects of the hospital environment (inpatient hospital, maternity hospital) and poultry farms (hatchery, chicken breeding department) has been confirmed. The polyresistance of P. aeruginosa isolates to antibacterial preparations has been established. A tendency to decrease in the sensitivity of the pathogen against the preparation of the group of cephalosporins, fluoroquinolones, aminoglycosides has been confirmed. Conclusions and prospects for further research. The effectiveness of the proposed anti–bacterial preparation Saroflox against P. aeruginosa in the concentrations from 0.078 to 10% and its more pronounced activity compared to enrofloxacin has been established.
Authors and Affiliations
Tatyana Fotina, Yevgenia Vashchyk, Roman Shcherbyna
Keywords
Related Articles
- EP ID EP407680
- DOI 10.31073/vet_biotech32(2)-70
- Views 109
- Downloads 0
Значення фітокомпонента в середовищі культивування для продуцентів нових синбіотичних препаратів
Препарати з пробіотичними властивостями на основі активних пробіотичних штамів мікроорганізмів і фітокомпонентів сприяють нормальному розвитку тварин, опірності до негативних впливів довкілля. Поєднання екстракту амарант...
Diagnostic features of factor infections in young cattle
Introduction. Currently, with the intensification of animal husbandry, so-called factor diseases (FB) are especially dangerous. These are diseases, the development of which occurs in the presence of various unfavorable c...
Enzyme-linked immunosorbent assay in the diagnosis of hepatitis E in pigs
Introduction. Hepatitis E has long been seen as an infectious disease that is detected in developing countries, both among humans and animals. Some strains infect only humans or animals, while others can infect both. Det...
The contemporary aspects of the algorithm of diagnostics of dermatitis of parasitic etiology
Introduction. At the present, the pathology of skin in dogs occupies a significant place among diseases of the different genesis and is an urgent issue that has not been adequately researched by specialists in veterinary...
Hematological indicators of the blood of rabbits vaccinated by experimental samples of vaccines “Velshisan”, “Velshisan+AUNP” “Velshisan+AUNP-stimul”
Introduction. Vaccinology is one of the most important areas of medicine. This science is engaged in the development of vaccines, the study of the immune response and the influence of the vaccine components on the organi...