The Protective Effect of White and Red Radish as Hypoglycemic and Hypocholesterolemic Agents
Journal Title: IOSR Journal of Pharmacy and Biological Sciences (IOSR-JPBS) - Year 2016, Vol 11, Issue 3
Abstract
Radish, Raphanus Sativus L. (family: Brassicaceae) has been recognized since ancient times, roots and leaves are used for cooking and treatment of a wide variety ailments. White radish leaves (WRL), white radish roots (WRR) and red radish roots (RRR) were used in this study. Four major active compounds were identified by HPLC in the methanolic extracts of radish, those included catechin, ferulic, sinapic and coumaric acid. The edible parts of radish were used as hypoglycemic and hypocholesterolemic experiments by using albino rats. Water extracts of WRL, WRR and RRR were administered orally at doses 100, 200 and 400 mg/kg b.w/day/rat. Results show the effect of the extracts on glucose level of diabetic rats. The highest effect of tested radish extracts was with G12 (rats administered 400 mg RRR/kg b.w/day). Also, there was a significant decrease in TG, TC, LDL-c and increase in the HDL-c parameter in G12. Furthermore, results of the influence of WRL, WRR and RRR as hypocholesterolemic action was in a positive way especially G12 of RRR on the reduction of the levels of TC, LDL-c and TG and increased the level of glutathione peroxidase. Moreover, results of G11 show the reduction of malodialdehyde (MDA) in serum of rats. G11(HFD(high fat diet) + 1%cholesterol +400 mg RRR/kg b.w/day)recorded the best results as hypocholesterolemic effect which could be attributed to the content of main phenolic acids in red radish roots in high level. Our results indicates the hypoglycemic and hypocholesterolemic effect of radish extracts.
Authors and Affiliations
Mona Mohamed Abdel Magied, Ahmed Mohmoud Alian 1, Lobna Abdel Fattah, Mohamed Haerrdy, Marwa Taha Hussein
Keywords
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- EP ID EP384578
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