Anti-Obesity Potential of Heritiera Fomes Leaves Methanolic Extract in a Preclinical Model
Journal Title: IOSR Journal of Pharmacy and Biological Sciences (IOSR-JPBS) - Year 2017, Vol 12, Issue 4
Abstract
Objective: This study was undertaken to evaluate the anti-obesity potential of the methanolic extract of leaves of Heritiera fomes. (MEHF) in high fat cafeteria diet (HFCD) fed obese rats. Methods: Wistar strain of albino rats were divided into six groups comprising of six rats each. Group I served as normal control fed with normal pellet chow, group II served as disease control fed with high fat cafeteria diet, group III, IV and V animals, received MEHF at a dose level of 100, 200 and 400mg/kg b.w along with HFCD for 40 days, while, group VI served as standard drug control, which received Orlistat at a dosage of 50mg/kg b.w along with HFCD. Results: Administration of HFCD for 40 successive days to experimental rats significantly increased the body weight, organ and fat pad weights, serum total cholesterol, LDL cholesterol, VLDL cholesterol, triglycerides and glucose levels; and decreased HDL cholesterol as compared to normal control. While treatment with MEHF showed a significant reduction in the body weight gain, organ weight of the liver, kidney, spleen, weight of fat pads and the levels of serum triglycerides, total cholesterol, LDL cholesterol, VLDL cholesterol, glucose and increase in HDL cholesterol in a dose dependent manner. Further, the levels of liver markers such as aspartate transaminase (AST), alanine transaminase (ALT) and alkaline phosphatase (ALP), which were found to be elevated in the serum of obese rats, also resumed to normal on treatment with different concentrations of MEHF. Moreover, the consumption of MEHF reduced oxidative stress by enhancing the levels of glutathione (GSH), glutathione peroxidase (GPx), super oxide dismutase (SOD) and catalase in the hepatic tissue of rats with HFCD induced obesity. Conclusion: These results demonstrate clearly that repeated oral administration of Heritiera fomes methanolic extract can evoke a potent anti-obesity activity.
Authors and Affiliations
*M. Salim Mirza1, Sayed Ayaz Ali2, Indrajeet Sanghvi3
Keywords
Related Articles
- EP ID EP389889
- DOI 10.9790/3008-1204010105
- Views 83
- Downloads 0
In vitro anticancer activity of methanol extract of Cladophora spp. against HT-29 cell line
The anticancer activity of the marine alga Cladophora spp. against HT-29 colon cancer cell line was studied. In the present investigation crude extract of seaweed was prepared by using soxhlet apparatus. Methanol was use...
Anti-tumour Activity of Aqueous Wheat Grass Extracts against Chemically Induced Carcinogenesis
Cancer is the leading cause of death globally and in 2015, cancer accounted for 8.8 million deaths worldwide. Liver cancer is the second most common type of cancer after lung cancer, causing many fatalities in both devel...
Assessment of Efficacy and Safety of Newly Formulated Natural Sun Protective Cream
This research aims to formulate and evaluate the photo protective activity of an cream containing oil in water emulsion with different natural oils in varying proportions. The formulation is evaluated for its physical, c...
Comparative Larvicidal and Residual Activity of Bacillus Thuringiensisvar. Israelensisand Temephos (1.0 % Sg) In Granules Against Culex Pipiens Pallens(Diptera: Culicidae) In Semi-Field Tests
The study looked at comparative larvicidal activity and residual effects of granular formulations of Bacillusthuringiensis var. Israelensis (Bti); a bio pesticide and temephos (Abate); phosphorus based nonsystemic pestic...
The Role of M1/M2 Transition of the Brain Macrophages in Alzheimer’s Disease
Alzheimer’s disease (AD) is a neurodegenerative disorder that is characterized by the presence of neurofibrillary tangles (NFT) and senile plaques caused due to amyloid beta (Aβ) aggregation in the brain. Macrophage like...