Anti-Obesity Potential of Heritiera Fomes Leaves Methanolic Extract in a Preclinical Model

Journal Title: IOSR Journal of Pharmacy and Biological Sciences (IOSR-JPBS) - Year 2017, Vol 12, Issue 4

Abstract

Objective: This study was undertaken to evaluate the anti-obesity potential of the methanolic extract of leaves of Heritiera fomes. (MEHF) in high fat cafeteria diet (HFCD) fed obese rats. Methods: Wistar strain of albino rats were divided into six groups comprising of six rats each. Group I served as normal control fed with normal pellet chow, group II served as disease control fed with high fat cafeteria diet, group III, IV and V animals, received MEHF at a dose level of 100, 200 and 400mg/kg b.w along with HFCD for 40 days, while, group VI served as standard drug control, which received Orlistat at a dosage of 50mg/kg b.w along with HFCD. Results: Administration of HFCD for 40 successive days to experimental rats significantly increased the body weight, organ and fat pad weights, serum total cholesterol, LDL cholesterol, VLDL cholesterol, triglycerides and glucose levels; and decreased HDL cholesterol as compared to normal control. While treatment with MEHF showed a significant reduction in the body weight gain, organ weight of the liver, kidney, spleen, weight of fat pads and the levels of serum triglycerides, total cholesterol, LDL cholesterol, VLDL cholesterol, glucose and increase in HDL cholesterol in a dose dependent manner. Further, the levels of liver markers such as aspartate transaminase (AST), alanine transaminase (ALT) and alkaline phosphatase (ALP), which were found to be elevated in the serum of obese rats, also resumed to normal on treatment with different concentrations of MEHF. Moreover, the consumption of MEHF reduced oxidative stress by enhancing the levels of glutathione (GSH), glutathione peroxidase (GPx), super oxide dismutase (SOD) and catalase in the hepatic tissue of rats with HFCD induced obesity. Conclusion: These results demonstrate clearly that repeated oral administration of Heritiera fomes methanolic extract can evoke a potent anti-obesity activity.

Authors and Affiliations

*M. Salim Mirza1, Sayed Ayaz Ali2, Indrajeet Sanghvi3

Keywords

Related Articles

Sedative, Analgesic and Cytotoxic activities of Nyctanthes arbor-tristis L.

Nyctanthes arbor-tristis L. is a flowering plant widely distributed in Bangladesh as well as all over tropical and subtropical regions of Southeast Asia. It has been used in traditional medicine for its various pharmacol...

Interactions Between Vascular Arbuscular Mycorrhizal Fungi And Streptomyces As Biocontrol Agent For Tomato Damping-Off Disease Caused By Rhizoctonia SolaniKuhn

The most popular and important plant Lycopersicon esculentum Mill or Tomato was attacked by several fungal pathogens and several biocontrol agents can be used. Mycorrhizal fungi are mutuality associated with many plant r...

Effect of additives on Pleurotus ostreatus Growth on Agar medium

Oyster mushroom (Pleurotus ostreatus) is one of the most widely grown mushrooms worldwide. This type of fungus have been grown for centuries in green houses to produce mycelium and fruiting bodies and marketed as highly...

Evaluations of Some Biological Properties of Ethanolic Leave Extract of Costus Afer (Ker Gawl).

Costus afer plant has been known to the traditionalist for a very long time. The locals having realized its medicinal potentials have employed it in a variety of ways. This study was designed to investigate the antimicro...

Detection of Some Biomarkers in Iraqi Patients with Thyroid Carcinoma

Background:Thyroid cancer, the most common endocrine malignancy, has increased dramatically in the lastyears.Cathepsin D and Galectin-3 have been implicated in the regulation of cellular growth, differentiation and malig...

Download PDF file
  • EP ID EP389889
  • DOI 10.9790/3008-1204010105
  • Views 92
  • Downloads 0

How To Cite

*M. Salim Mirza1, Sayed Ayaz Ali2, Indrajeet Sanghvi3 (2017). Anti-Obesity Potential of Heritiera Fomes Leaves Methanolic Extract in a Preclinical Model. IOSR Journal of Pharmacy and Biological Sciences (IOSR-JPBS), 12(4), 1-5. https://europub.co.uk/articles/-A-389889