The Protective Effects of Antioxidant (Vitamin C) Against Hepatic Oxidative Damage Induced by Zinc Oxide Nanoparticals
Journal Title: International Research Journal of Applied and Basic Sciences - Year 2015, Vol 9, Issue 4
Abstract
It has demonstrated that nanoparticles, may cause more inflammation than larger particles of the same materials at a same mass dose. The aim of this study was to investigate the role of vitamin C against the toxic effect of zinc oxide nano-particles (ZnO-NPs) induced oxidative stress in rat livers. ZnO-NPs were administered orally using two doses (300 mg and 1g/kg body weight/day for two weeks) in two test groups of rats, another two test groups were received the same doses in addition to vitamin C (30 mg/kg body weight) daily for four weeks. Some biomarkers of tissue damage were investigated. Indices of different antioxidant enzymes (namely, superoxide dismutase, catalase, glutathione-S-transferase) as well as lipid peroxidation and glutathione were determined in liver homogenates. Finally, histopathological studies were performed from liver sections of all rats of all groups.administration of either low or high repeated doses of ZnO-NPs to rats significantly increased liver function biomarkers. It also increased reactive oxygen species production and reduced the levels of antioxidant enzymes and cellular reserves of glutathione in liver homogenate. Co-administration of vitamin C significantly reversed these changes to almost normal. Apart from these, histopathological changes also revealed the protective nature of vitamin C against ZnO-NPs induced necrotic damage of the liver tissues.vitamin C proved to be hepatoprotective agents against ZnO-NPs toxicity because they ameliorated the oxidative stress related to liver damage.
Authors and Affiliations
Dalal Nemenqani| Department of Pathology, Collage of Medicine, Taif University, KSA, Osama El-Gharib| Clinical Pharmacology, Collage of Medicine, Taif University, KSA, Amany M. Ahmed| Clinical Pharmacology, Collage of Medicine, Taif University, KSA, Ayman R. Baiuomy| Clinical Pharmacology, Collage of Medicine, Taif University, KSA
Keywords
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