The Protective Role of Agaricusbisporusin Experimental Liver Injury in Mice
Journal Title: IOSR Journal of Pharmacy and Biological Sciences (IOSR-JPBS) - Year 2018, Vol 13, Issue 1
Abstract
Hepatic disorders can develop by many causative agents like Reactive oxygen species (ROS). Various antioxidants have been ensured to protect against hepatic damage. The aim of this study is to ensure Agariusbiporus protective effects in experimental mice of liver injury.Forty adult female albino mice were divided to five groups (Ten mice for eachgroup), the first group give normal saline as control, the second one treated with 2ml/kg body weight of peroxide(H2O2) withdrinking water,the third one treated with water aqueous extract (25) mg/ml ofA.bisporusorallywith H2O2 in drinking water and finally the fourth one treated withaqueous extract (25) mg/ml of A.bisporus orally by use of intragastric tube. Results for apoptosis test showed peroxide treated group induced apoptosis while aqueous extract of A. bisporustreated group with peroxide inducednon-apoptotic. Histopathological examination of liver cells exposed to H2O2 showed necrosis and degenerated liver cells by the evidence of tendency to forming granuloma. In sinusoids showed dilation with severe congestion of blood vessel while the tissue treated with (2) ml/kgbody weight of A.bisporus and H2O2 with drinking water showedslightly congested blood vesseland aggregation of mononuclear cells in liver parenchyma. The liver tissue in mice treated with (2) ml/kgbody weightof A.bisporus appeared approximately like the normal tissue.We conclude that the aqueous extract of Agaricusbisporuscan protect the liver against peroxide induced oxidative damage in mice and is an efficient antioxidant agent and hepatoprotectiveagainst peroxide induced liver injury.
Authors and Affiliations
Dina KhudhairHussein Ali, Rusol Al-BahranI, SuraMuayad Abdel Majeed
Keywords
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- EP ID EP393250
- DOI 10.9790/3008-1301022328
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