The relationship between -C344/T aldosterone synthase (CYP11B2) gene polymorphism, enzyme activity level and increased risk of nonvalvular atrial fibrillation
Journal Title: Family Medicine & Primary Care Review - Year 2015, Vol 17, Issue 2
Abstract
Background. Aldosterone plays an important role in the pathogenesis of non-familial AF. The aldosterone synthase gene (-C/344T CYP11B2) encodes aldosterone synthase – the enzyme that catalyzes the final reaction to generate aldosterone.Despite several investigation studies of association between -C/344T CYP11B2 gene polymorphism, enzyme activity and atrial fibrillation (AF) presence, their results still remain controversial.Objectives. To examine the association between the -C/344T CYP11B2 gene polymorphism, enzyme activity level and risk of nonvalvular AF development. Material and methods. The authors observed 45 patients with nonvalvular paroxysmal (group 1, n = 28) and persistent AF (group 2, n = 17) on the background of ischemic heart disease and/or hypertension, without significant structural myocardial damage. The third – control group – consisted of 39 subjects without cardiovascular diseases and history of arrhythmias.Patients were genotyped for the CYP11B2 gene polymorphism using the polymerase chain reaction. Aldosterone synthase enzyme activity in plasma was also determined. Results. In patients with AF the frequency of T/T genotype and T-allele was significantly higher than in the control group. The total number of AF-rhythm disorders was associated with the increased T-allele frequency. Aldosterone synthase enzyme activity level was significantly higher in patients with persistant AF and TT-genotype versus patients of other genotypes in this group and in all patients in the control group. Conclusions. TT-genotype and T-allele of -C344/T CYP11B2 gene associates so with nonvalvular AF presence, as with significantly higher aldosterone synthase activity level in patients with persistant AF. Patients with TT-genotype have higher risk of AF development.
Authors and Affiliations
KatsiAryna Yatskevich, Viktor Snezhitskiy, Mikhail Kurbat, Tatiana Stepuro
Keywords
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