The relationship between I-131 uptake in postoperative residue thyroid tissue and absorbed doses calculated with MIRDOSE3 and pre-ablation thyroglobulin levels in patients with differential thyroid cancer: A retrospective comparison study
Journal Title: Cumhuriyet Medical Journal - Year 2018, Vol 40, Issue 1
Abstract
Objective: The aim of this study was to compare I-131 uptake in postoperative residue thyroid tissue and absorbed doses calculated with MIRDOSE3 and pre-ablation thyroglobulin levels in patients with differential thyroid cancer and was to investigate whether there is a relationship in terms of effectiveness to treatment efficacy. Method: Seventy-four patients were included in the study. Serum thyroglobulin and thyroid stimulating hormone levels before ablation were measured in patients. Uptake values were calculated using I-131 whole body scan scintigraphy images taken on the 8th day after ablation. The findings were evaluated with low dose I-131 whole body scan scintigraphy at 8th-12th months after ablation. Also the effective half-life of I-131, cumulative activity and I-131 residence time were calculated for each patient. The values found were used in the MIRDOSE3 program to calculate total body absorptive doses and comparison was made between the parameters. Results: Thyroglobulin values and uptake values were compared with sperman analysis. There was intermediate correlation between them (r = 0.616, p = 0.01). There was a low correlation in the negative direction between thyroid stimulating hormone levels and uptake values of patients before ablation (r =-0.218, p = 0.05). In 74 patients 8th-12th. Month whole body scan scintigraphy and thyroglobulin results are evaluated; 3 (4.1%) patients were not complete ablated and 71 patients (95.9%) were complete ablated. There was a significant difference only in the thyroglobulin value between complete ablated and non-ablated patient groups (p =0.001). There was a low correlation between absorbed doses and thyroglobulin values (r = 0.212, p = 0.05). Conclusions: As a result, we observed that thyroglobulin values measured before I-131 treatment inform about residual tissue after surgery and residual tissue size may affect treatment efficacy. We also think that attention should be paid to the treatment and follow-up protocol in terms of complete ablation success in patients with high pre-treatment thyroglobulin values.
Authors and Affiliations
Fadime Demir, Zekiye Hasbek, Taner Erselcan, Bülent Turgut
Keywords
Related Articles
- EP ID EP272038
- DOI 10.7197/223.vi.407628
- Views 96
- Downloads 0
Children and health effects of war Being a war child...
It’s predicted that almost 10 million children as died at wars during the last decade, almost 300 thousand children fight more than 30 engagement area. Situations arising from armed conflict effect first of all children...
Acute inferior ST segment elevation myocardial infarction due to chemotherapy in a young man with testicular cancer
Testicular cancer is the most common malignancy in men between 15 and 29 years of age. cisplatin, etoposide and bleomycin combination chemotherapy remains the mainstay of testicular cancer treatment. Acute myocardial inf...
Usnic acid uses mitochondrial apopitotic pathway in it’s antitumoral role
Objective: Usnic acid is a secondary metabolite in lichens whose role has not been completely elucidated. Lichen extracts containing usnic acid have been utilized in medicine, perfumery, cosmetics, and ecology. Usnic asi...
Clinical symptoms of rat acute peritonitis model and study over effects of oral strontium ranelate administration for the treatment
Objective: Despite the improvements in the treatments of surgical and intensive care, sepsis and systemic inflammatory response syndrome are the most common cause of mortality. Therefore in the experimental animal model,...
Acinetobacter-associated nosocomial infections in Cumhuriyet University Medical Faculty Research Hospital: Three years’ experience
Objective: Nosocomial infections have high mortality and morbidity. Acinetobacter is a Gram-negative bacilli and an important nosocomial pathogen. The number of nosocomial infections caused by antibiotic resistant-Acinet...