The Relationship Between Leptin and Norepinephrine Levels During OGTT in Normotensive and Hypertensive Obese Adolescents <br />
Journal Title: Journal of Clinical Research in Pediatric Endocrinology - Year 2009, Vol 1, Issue 4
Abstract
Background/Aims: Studies in adult population have suggested that leptin might play a role in inducing obesity related hypertension mediated by the sympathetic nervous system. This association has not been established for adolescents. Our study is designed to explore the relationship between leptin and norepinephrine levels in pediatric patients and to identify any contributors to hypertension for this population. Methods: Thirty-nine obese adolescents, divided into four groups by gender and hypertension status were included in the study. Leptin and norepinephrine levels were measured during oral glucose tolerance tests (OGTT) to optimize hormonal secretion. T tests were used to compare baseline levels of glucose, insulin, leptin and norepinephrine at 0 hour point of OGTT between the hypertensive and normotensive patients for both genders. Analysis of covariance (ANCOVA) was used for comparison of subsequent levels between the hypertensive and normotensive groups for in both genders, with the corresponding baseline level as the covariance. Models with and without BMI adjustment were created and their results were found to be consistent. Correlation between leptin and norepinephrine was examined at each time point and through analysis of area under the curve (AUC). Results: Contrary to the previous findings obtained in adult patients, our results did not show any direct relationships between levels of leptin and norepinephrine. A slight decrease in norepinephrine level at 1 hour in the normotensive male group and a significant increase in leptin level at 1 hour in the hypertensive female group was observed. Conclusion: Our preliminary data suggest that norepinephrine and leptin levels at 0 and 1 hour during routine OGTT, for males and females, respectively, may help identify a subgroup of obese adolescents who have higher risk for hypertension and cardiovascular complications. DOI: 10.4008/jcrpe.v1i4.57
Authors and Affiliations
Ping Zhou, Raphael David, Bina Shah
Keywords
Related Articles
- EP ID EP149852
- DOI -
- Views 96
- Downloads 0
Al-Awadi/Raas-Rothschild Syndrome in a Newborn with Additional Anomalies
Al-Awadi/Raas-Rothschild (AARR) syndrome is a rare phocomelia syndrome characterized by limb/pelvic hypoplasia/aplasia, renal anomalies such as horseshoe and polycystic kidney, and abnormal facial features including clef...
Hypothalamo-Pituitary Insufficiency Associated with Ectrodactyly-Ectodermal Dysplasia-Clefting Syndrome
Ectrodactyly-ectodermal dysplasia-clefting (EEC) syndrome is characterized by ectodermal dysplasia, ectrodactyly and facial clefting with multiple congenital anomalies such as urinary tract anomaly, lacrimal duct obstruc...
Constitutional Growth Delay Pattern of Growth in Velo-Cardio-Facial Syndrome: Longitudinal follow up and final height of two cases
We report two patients with velo-cardio-facial syndrome (VCFS) who were admitted to our pediatric endocrinology clinic because of short stature and followed longitudinally until attainment of final height. Both patients...
Precocious Puberty and Normal Variant Puberty: Definition, etiology, diagnosis and current management
This review describes several aspects of the management of precocious puberty (PP) and variants in girls and boys. PP is characterized by early pubertal changes, acceleration of growth velocity and rapid bone maturation...
Myasthenia Gravis Hasta Timektomi sonra Otoimmün ooforit Kararı
Myastenia gravis (MG), asetilkolin reseptörlerine karşı otoantikorlar ile karakterize otoimmün bir hastalıktır . MG genellikle izole bir hastalık ama diğer otoimmün hastalıklar ile birlikte oluşabilir. Biz, sekonder amen...