The relationship between prognostic parameters and tumor associated tissue eosinophilia in supraglottic laryngeal tumors
Journal Title: Dicle Tıp Dergisi - Year 2013, Vol 40, Issue 1
Abstract
Objective: Tumor-associated tissue eosinophilia (TATE) has been noted in human cancers, sometimes with different results regarding their association with clinical outcome. In this study, the association between TATE and prognostic parameters of supraglottic laryngeal cancer was analyzed. Materials and methods: Sixty-two patients with diagnosis of supraglottic laryngeal squamous cell carcinoma and who treated surgically in our center were evaluated. The cases were divided into 3 categories according to the average number of eosinophils per high-power field (400x): 0 (negative), 1-5 (grade 1+), more than 5 (grade 2+). Results: We found 24 TATE-negative (38.7%) and 38 TATE-positive (61.3%) cases. There was not any statistically significant correlation between TATE and tumor differentiation, vascular invasion, perineural invasion, lymph node metastasis, patients’ ages, T stages (p>0.05). As expected, vascular invasion correlated with lymph node metastasis (p=0.001). Conclusion: The results of this study showed that TATE has no correlation with prognostic parameters such as histologic differentiation, vascular invasion, perineural invasion, lymph node metastasis, patients’ ages and T stages in supraglottic laryngeal squamous cell carcinoma. The data suggest that stromal eosinophilic infiltration is not useful for determining biological aggressiveness in supraglottic laryngeal cancer. Key words: laryngeal carcinoma, supraglottic, eosinophilia, prognostic parameters
Authors and Affiliations
Ali Süner, Ediz Tutar, Mehmet Kalender, Ülkü Kazancı, Sibel Arslan, Ozan Balakan, Erkan Karataş, Muzaffer Kanlıkama
Keywords
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- EP ID EP103930
- DOI doi: 10.5798/diclemedj.0921.2013.01.0222
- Views 139
- Downloads 0
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