The relationship between prognostic parameters and tumor associated tissue eosinophilia in supraglottic laryngeal tumors
Journal Title: Dicle Tıp Dergisi - Year 2013, Vol 40, Issue 1
Abstract
Objective: Tumor-associated tissue eosinophilia (TATE) has been noted in human cancers, sometimes with different results regarding their association with clinical outcome. In this study, the association between TATE and prognostic parameters of supraglottic laryngeal cancer was analyzed. Materials and methods: Sixty-two patients with diagnosis of supraglottic laryngeal squamous cell carcinoma and who treated surgically in our center were evaluated. The cases were divided into 3 categories according to the average number of eosinophils per high-power field (400x): 0 (negative), 1-5 (grade 1+), more than 5 (grade 2+). Results: We found 24 TATE-negative (38.7%) and 38 TATE-positive (61.3%) cases. There was not any statistically significant correlation between TATE and tumor differentiation, vascular invasion, perineural invasion, lymph node metastasis, patients’ ages, T stages (p>0.05). As expected, vascular invasion correlated with lymph node metastasis (p=0.001). Conclusion: The results of this study showed that TATE has no correlation with prognostic parameters such as histologic differentiation, vascular invasion, perineural invasion, lymph node metastasis, patients’ ages and T stages in supraglottic laryngeal squamous cell carcinoma. The data suggest that stromal eosinophilic infiltration is not useful for determining biological aggressiveness in supraglottic laryngeal cancer. Key words: laryngeal carcinoma, supraglottic, eosinophilia, prognostic parameters
Authors and Affiliations
Ali Süner, Ediz Tutar, Mehmet Kalender, Ülkü Kazancı, Sibel Arslan, Ozan Balakan, Erkan Karataş, Muzaffer Kanlıkama
Keywords
Related Articles
- EP ID EP103930
- DOI doi: 10.5798/diclemedj.0921.2013.01.0222
- Views 138
- Downloads 0
Analysis of 36 patients underwent cochlear implantation surgery
Objectives: The aim of this study was to analyze the etiology, surgical methods and complications of the patients who underwent cochlear implantation (CI) for bilateral sensorineural hearing loss. Materials and metho...
Current pharmacological agents for the treatment of premature ejaculation
This study was aimed to review and assess the update studies regarding medical treatment for premature ejaculation (PE). It is the most common sexual problem affecting men. It can affect men at all ages and has a serious...
Meckel-Gruber Sendromu: Dokuz olgu sunumu ve literatürün incelenmesi
Amaç: Meckel-Gruber Sendromu sistemik malformasyonlar ile karakterize otozomal resesif, ölümcül bir sendromdur. Akraba evliliklerinin sık olduğu bölgemizde 6 aylık bir sürede 9 olguda tanı konulmuştur. Mevcut veril...
A rare case: Raine Syndrome
Ultrasonography technical developments in the early diagnosis of fetal anomalies in utero has helped. However, a very rare anomaly in utero, or diagnosed late and can be skipped. In this case affect families in a way tha...
Tiroid hormone direnci: nadir bir sendrom
Tiroid hormon direnci sendromu (RTH) genellikle otozomal dominant kalitim gösteren nadir bir hastalıktır. Tiroid hormon direnci olan hastalar genellikle ötiroid olurlar fakat nadir de olsa tirotoksikoz veya hipotiroidizm...