The relationship between the body mass index and the Firmicutes/Bacteroidetes ratio in the intestinal microbioume of the adult population of Ukraine
Journal Title: Сучасна гастроентерологія - Year 2018, Vol 0, Issue 1
Abstract
Objective — to investigate the difference in the composition of the main intestinal microbiota types in the adult population of Ukraine and their relationship with the body mass index (BMI). Materials and methods. Investigation involved 61 adult people (15 men and 46 women) aged 19 to 76 years (the mean age 44.3 ± 1.6 years). Patients were allocated into four groups depending on the BMI value: I group with BMI < 18.5 kg/m2 (underweight), ІІ group with BMI 18.5 to 24.9 kg/m2 (normal weight), ІІІ with BMI 25.0 to 29.9 kg/m2 (overweight), ІV with BMI ≥ 30.0 kg/m2 (obese). Levels of Actinobacteria, Firmicutes, Bacteroidetes and Firmicutes/Bacteroidetes (F/B) ratio in faeces were analyzed. Results. It has been established that with BMI increase, the Firmicutes count gradually increased, and Bacteroidetes decreased, respectively, the F/B ratio raised. In the unadjusted logistic regression model, F/B ratio was associated with BMI (OR = 1.23, 95 % CI 1.09 — 1.38), which remained significant after adjusting such factors as age, gender, physical activity and smoking (OR = 1.33, 95 % CI 1.11 — 1.60). Conclusions. Сomposition of intestinal microorganisms in adults with overweight and obesity in Ukraine is characterized with a significantly higher Firmicutes levels and lower Bacteroidetes levels when compared to normal-weight and underweight adults.
Authors and Affiliations
O. K. Kolyada, G. K. Syzenko, V. V. Moseiko, L. O. Budovska, K. S. Puchkov, Yu. V. Havalko, O. M. Vaiserman, M. S. Romanenko
Keywords
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