The Relationship between Thyroid Hormone Levels and Body Iron Status in Iranian Hypothyroidism Patients
Journal Title: International Journal of Medical Laboratory - Year 2016, Vol 3, Issue 3
Abstract
Backgrounds and Aims: Thyroid hormones have a crucial physiological role to maintain balance of metabolism of body. Thyroid hormones have an important role in metabolism and proliferation of blood cells. Thyroid gland also has a vital influence on erythropoiesis by induction of erythropoietin secretion and proliferation of erythroid progenitors. In the present study, it was tried to evaluate the effect of hypothyroidism on hematological parameters and also body iron store. Materials and Methods: The research population consisted of 90 subjects divided into two groups: 45 people with hypothyroidism and 45 age-matched healthy individuals. This study checked the amounts of total triiodothyronine (T3), total thyroxine (T4), thyroid stimulating hormone (TSH), and some iron status and hematological parameters. Results: The mean TSH levels were significantly increased in hypothyroid patients compared to control group. On the other hand, the levels of T4 and total iron binding capacity, serum iron, ferritin, Hemoglobin, and Hematocrit were significantly lower in hypothyroid patients compared to control group (p<0.05). However, there was no significant difference in the mean of T3 between hypothyroidism and control. Conclusion: Our data suggest that alterations in thyroid status change serum iron metabolism and hematological index. Hypothyroidism is often associated with anemia,depleted body iron store. As there is no significant clinical manifestation of hypothyroidism at earlier stages with anemia, it is advisable to routinely investigate it for early detection allowing its early management.
Authors and Affiliations
Niko Rostaei Rad, Mahmood Vakili, Javad Zavar-reza, Sona Rezaie, Ahmad Reza Shirvani
Keywords
Related Articles
- EP ID EP212558
- DOI -
- Views 127
- Downloads 0
Association of ABO Blood Group System and Anti-Sperm Antibody with Male Infertility
Background and Aims: The ABO blood group system is recognized as major and clinically significant blood group. This group is not only important in terms of blood transfusion and organ transplantation, but also has been u...
Advances in Hematopoietic Stem Cell Mobilization and Peripheral Blood Stem Cell Transplantation
Hematopoietic stem/progenitor cells (HSPCs) which give rise to different blood cell types are present within the bone marrow microenvironment, especially in flat bones such as skull, vertebrae, pelvis and chest. Interact...
Prevalence of Aeroallergens and Food Allergens in Allergic Patients in Tehran, Iran
Background and Aims: Identification of different allergens is a major challenge in allergic diseases. Avoiding these allergens is known as one of the best types of treatment. The aim of this study is to determine the pre...
Frequency of p53 Gene Codon 72 Polymorphisms in Women with Breast Cancer in Iran
Backgrounds and Aims: P53 gene is regarded important in pathogenesis of different cancers. Therefore, this study aimed to investigate the frequency of p53 gene codon 72 Arg/Pro polymorphism in women suffering from breast...
The Relation of Serum Bilirubin Level with the Severity and Complexity of Coronary Artery Disease and Long-term Outcomes in the Patients Undergoing Primary Percutaneous Coronary Intervention
Background and Aims: Bilirubin has been considered an antioxidant that protects against atherosclerosis. The aim of this study was to evaluate the relationship of serum bilirubin level with the severity and complexity of...