The Results of the Genetic Predisposition to Type 2 Diabetes Mellitus (Mitochondrial Diabetes) Determination Among Population of Prykarpattya Region According to the Indices of Carbohydrate Metabolism Evaluation
Journal Title: Lviv Clinical Bulletin - Year 2013, Vol 4, Issue 4
Abstract
Introduction. Considering the urgent need to optimize the methods for preventing diabetes mellitus, it is important to find the methods of early diagnosis of carbohydrate metabolism disorders that precede the manifestation of type 2 diabetes mellitus and to promote the method of self-monitoring of carbohydrate metabolism available in Ukraine and abroad for each family. In connection with the peculiarities of energy metabolism, the expediency of studying the pyruvate dehydrogenase activity of blood for the purpose of early diagnosis of diabetes mellitus is obvious. Aim. To identify the persons with a hereditary predisposition to type 2 diabetes mellitus (with mitochondrial diabetes) in the population of the Prykarpattya region using the assessment of carbohydrate metabolism. To recommend the use of a bloodless visual method of studying the total content of α-ketoacids in the urine. Materials and methods. Into the study there were involved 292 practically healthy residents of the Prykarpattya region (166 men and 126 women aged 6 to 80 years) in which the blood glucose level did not exceed 5.6 mmol (100.8 mg%). The state of carbohydrate metabolism was evaluated using pyruvate dehydrogenase and α-ketoglutarate dehydrogenase tests. The monitoring was performed by indicators of pyruvate dehydrogenase activity in blood of healthy persons in the range of 8.01-16.30 μcat/l, as well as the 2-hour α-ketoneuria (6.4-11.4 mg, p <0,01), which was accepted as normal. Results Hereditary predisposition to type 2 diabetes mellitus (mitochondrial diabetes) was detected in 40.76% of the subjects. Of these, 7.88% is due to pyruvate dehydrogenase deficiency and 32.88% of α-ketoglutarate dehydrogenase deficiency. It let us determine a genetic predisposition to type 2 diabetes mellitus (mitochondrial diabetes) in 40.76 % of the patients, in particular, in 7.88 % – due to pyruvate dehydrogenase deficiency and in 32.88 % – due to α-ketoglutarate dehydrogenase deficiency. Conclusions. So, it is recommended to use at home a bloodless visual research method of α-keto acids total amount detection in the urine available to every family, as an effective way of self-control of carbohydrate metabolism, which will facilitate the identification of the individuals with inherited predisposition to the disorders of carbohydrate metabolism (mitochondrial diabetes), followed by the manifestation of type 2 diabetes mellitus and will allow to take the necessary measures to prevent its occurrence.
Authors and Affiliations
Ya. Tomashevskiy, Yu. Vendzylovych, N. Tomashevska, L. Hrupovych, M. Hrupovych, I. Sulyga
Keywords
Related Articles
- EP ID EP257994
- DOI 10.25040/lkv2013.04.023
- Views 90
- Downloads 0
Peculiarities of Inflammation, Oxidative/Nitrosative Stress in L-Ornithine-Induced Acute Pancreatitis
Introduction. The pathogenesis of acute pancreatitis (AP) continues to be a mystery to scientists. However, significant achievements in the field of fundamental research in the last decade have improved the information o...
Особенности оказания помощи беременным с лейомиомой матки
Введение. В настоящее время наблюдается прогрессивное увеличение комбинации беременности и лейомиомы матки. Наличие лейомиомы матки связано с высоким риском материнских и перинатальных осложнений. Поиску современных мето...
Clear Cell Acanthoma/Pseudolymphoma: Clinical Dermatoscopic and Histological Correlation
Introduction. Skin tumors make up the largest group due to the complex structure of this organ. Benign skin tumors are one of the most common pathologies that occupy an intermediate position at the interface of dermatol...
Remodelling Features of Heart and Postinfarction Cardiosclerosis Type 2 Diabetes: Relationship to Gene Polymorphisms LEPR Q223R
Objective. To establish the features of cardiac remodeling in patients with postinfarction cardiosclerosis and type 2 diabetes based on gene polymorphism leptin receptors LEPR Q223R. Materials and methods. The study invo...
Laparoscopic Cholecystectomy in Patients with Mild Acute Biliary Pancreatitis
Introduction. Over the last few decades, the incidence of acute pancreatitis is increasing, partly due to the increasing number of patients with cholelithiasis, which is the reason of 27,0-62,0 % of cases. Therefore, an...