The Results of the Genetic Predisposition to Type 2 Diabetes Mellitus (Mitochondrial Diabetes) Determination Among Population of Prykarpattya Region According to the Indices of Carbohydrate Metabolism Evaluation
Journal Title: Lviv Clinical Bulletin - Year 2013, Vol 4, Issue 4
Abstract
Introduction. Considering the urgent need to optimize the methods for preventing diabetes mellitus, it is important to find the methods of early diagnosis of carbohydrate metabolism disorders that precede the manifestation of type 2 diabetes mellitus and to promote the method of self-monitoring of carbohydrate metabolism available in Ukraine and abroad for each family. In connection with the peculiarities of energy metabolism, the expediency of studying the pyruvate dehydrogenase activity of blood for the purpose of early diagnosis of diabetes mellitus is obvious. Aim. To identify the persons with a hereditary predisposition to type 2 diabetes mellitus (with mitochondrial diabetes) in the population of the Prykarpattya region using the assessment of carbohydrate metabolism. To recommend the use of a bloodless visual method of studying the total content of α-ketoacids in the urine. Materials and methods. Into the study there were involved 292 practically healthy residents of the Prykarpattya region (166 men and 126 women aged 6 to 80 years) in which the blood glucose level did not exceed 5.6 mmol (100.8 mg%). The state of carbohydrate metabolism was evaluated using pyruvate dehydrogenase and α-ketoglutarate dehydrogenase tests. The monitoring was performed by indicators of pyruvate dehydrogenase activity in blood of healthy persons in the range of 8.01-16.30 μcat/l, as well as the 2-hour α-ketoneuria (6.4-11.4 mg, p <0,01), which was accepted as normal. Results Hereditary predisposition to type 2 diabetes mellitus (mitochondrial diabetes) was detected in 40.76% of the subjects. Of these, 7.88% is due to pyruvate dehydrogenase deficiency and 32.88% of α-ketoglutarate dehydrogenase deficiency. It let us determine a genetic predisposition to type 2 diabetes mellitus (mitochondrial diabetes) in 40.76 % of the patients, in particular, in 7.88 % – due to pyruvate dehydrogenase deficiency and in 32.88 % – due to α-ketoglutarate dehydrogenase deficiency. Conclusions. So, it is recommended to use at home a bloodless visual research method of α-keto acids total amount detection in the urine available to every family, as an effective way of self-control of carbohydrate metabolism, which will facilitate the identification of the individuals with inherited predisposition to the disorders of carbohydrate metabolism (mitochondrial diabetes), followed by the manifestation of type 2 diabetes mellitus and will allow to take the necessary measures to prevent its occurrence.
Authors and Affiliations
Ya. Tomashevskiy, Yu. Vendzylovych, N. Tomashevska, L. Hrupovych, M. Hrupovych, I. Sulyga
Keywords
Related Articles
- EP ID EP257994
- DOI 10.25040/lkv2013.04.023
- Views 121
- Downloads 0
Характеристика состояния костей у женщин в постменопаузе, больных системной красной волчанкой
Введение. Эпидемиологические исследования показывают, что распространенность остеопороза у больных системной красной волчанкой (СКВ) больше, чем в общей популяции, а это требует детального изучения его особенностей у так...
Углеводороды детерминанты гликополимеров ворсинок хориона эмбрионов человека, замерших вследствие спорадического и привычного невынашивания беременности
Введение. Понятие «невынашивание беременности» (НВ) включает самопроизвольное прерывание беременности в сроке от зачатия до 16-26-й недели развития, в зависимости от норм медицинского законодательства разных стран. Преры...
Iodine Deficiency Hypothyroidism in Residents of the Prykarpattia Region: Results of the First Phase of the Clinical Examination Using Pyruvate Dehydrogenase and α-ketonuria Tests
Introduction. According to a WHO study, about 30.0% of the Earth’s population is at an iodine deficiency (ID) risk; about 20 million people are mentally disturbed due to a deficit of iodine in the organism. The research...
Миофасциальный болевой синдром - некоторые аспекты диагностики и лечения
Введение. Боль спины случается в 40,0-80,0% популяции. Одной из самых частых причин боли спины является миофасциальный болевой синдром (МФБС). Около 84,0% взрослого населения хотя бы раз в жизни имеет эпизод боли в поясн...
Pathogenetic Mechanisms of the Occurrence of Rheumatoid Arthritis and Ankylosing Spondylitis with the Activation-Enzymatic and Phenotypic Features of Lymphocytes
Introduction. Significant prevalence of inflammatory diseases of the j oints, the tendency to steady increase in their severity, high indicators due to this temporary disability and disability, especially those of middle...