THE ROLE OF APOPTOSIS IN THE COURSE OF SEPSIS (LITERATURE REVIEW)
Journal Title: Молодий вчений - Year 2017, Vol 8, Issue 48
Abstract
The problem of neonatal sepsis is one of the unsolved problems of modern neonatology. The critical conditions of the newborn, including sepsis, are often accompanied by development of multiorgan dysfunction syndrome, which is associated with necrocytosis. Clinical and experimental observations suggest that the "programmable death" of cells by apoptosis plays important role in the mechanism of multiorgan mismatch. In recent years, experimental works have shown that сardiomyocytes are susceptible to apoptosis influenced of ischemia, immune inflammation and toxic factors. Further study of plasma markers of apoptosis (TNF-α, sFas / sFasL system, p53 and bcl-2) will contribute to a better understanding of mechanisms of cardiomyocytes damage in sepsis of newborns and help to optimize the early diagnosis of disease.
Authors and Affiliations
O. K. Koloskova, N. M. Kretsu
Keywords
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