The role of autologous hematopoietic stem cell transplantation in the treatment of multiple sclerosis
Journal Title: Postępy Nauk Medycznych - Year 2015, Vol 28, Issue 6
Abstract
Multiple sclerosis is a chronic disease of the central nervous system with inflammatory and neurodegenerative component and represents one of the leading causes of neurologic disability especially in young adults. Typical feature of multiple sclerosisis the presence within the structures of the central nervous system demyelinating plaques caused by autoimmune process with the involvement mainly of autoreactive T cells. Standard treatment strategies for multiple sclerosis are based on immunomodulatory drugs that affect the regulation of aberrant cell activity, as well as impaired balance in the production of pro- and anti-inflammatory cytokines. However, the use of interferon-β, glatiramer acetate as the first-line treatment, natalizumab and fingolimod as second-line one, has shown limited efficacy in patients with either a progressive or an aggressive disease course. There is growing evidence that autologous hematopoietic stem cell transplantation may be an alternative treatment modality for those patients. It is believed that through that procedure a significant amount of autoreactive lymphocytes is destroyed and by restoring the immune system of the patient organism is more resistant to the development of autoimmunity. This work summarizes recent views on the role of autologous hematopoietic stem cell transplantation in multiple sclerosis.
Authors and Affiliations
Sławomira Kyrcz-Krzemień, Dariusz Kata, Katarzyna Duda, Ewelina Lieber, Karolina Torba, Małgorzata Krawczyk-Kuliś, Grzegorz Helbig
Keywords
Related Articles
- EP ID EP77419
- DOI -
- Views 179
- Downloads 0
Trichological problems related to menopause
The menopause is associated with a cessation of ovarian synthesis of estrogens, what undoubtedly affects human skin functions and may cause some changes in hair distribution. An increase in androgen to estrogen ratio lea...
Stroke in the elderly – abnormalities
Consistent ageing of the society leads to higher stroke incidence. Within next 20 years stroke incidence is expected to increase by 40%. Most of strokes will occur in the elderly population. Apart from age, the most impo...
Iron and the liver – a novel approach to the old problem
Increased body iron storage leads to various, clinically relevant complications. Concepts of iron metabolism disturbance has evolved over last decades and historical theory of hemochromatosis being monogenic, intestinal...
Prevention and treatment of osteoporosis and urolithiasis
It was suggested that supplementation with calcium and vitamin D, which are essential components of prevention and therapy of osteoporosis, can increase the risk of kidney stone formation. Numerous studies showed, howeve...
Czy mocznica szczawianowa obserwowana na świńskim modelu ominięcia żołądka Roux-en-Y (RYGB) związana jest z niewydolnością zewnątrzwydzielniczą trzustki?
Wstęp. Niewydolność zewnątrzwydzielnicza trzustki (NZT) z reguły występuje po udanym zabiegu chirurgicznego ominięcia żołądka Roux-en-Y. Jednocześnie jednym z problemów występujących zarówno w przypadku NZT, jak i zabieg...