The role of biological sciences in understanding the genesis and a new therapeutic approach to Alzheimer’s disease
Journal Title: Advances in Hygiene and Experimental Medicine - Year 2011, Vol 65, Issue 0
Abstract
The paper contrasts the historical view on causal factors in Alzheimer’s disease (AD) with the modern concept of the symptoms’ origin. Biological sciences dealing with cell structure and physiology enabled comprehension of the role of mitochondrial defects in the processes of formation of neurofibrillary tangles and β-amyloid, which in turn gives hope for developing a new, more effective therapeutic strategy for AD. It has been established that although mitochondria constantly generate free radicals, from which they are protected by their own defensive systems, in some situations these systems become deregulated, which leads to free radical-based mitochondrial defects. This causes an energetic deficit in neurons and a further increase in the free radical pool. As a result, due to compensation processes, formation of tangles and/or acceleration of β-amyloid production takes place. The nature of these processes is initially a protective one, due to their anti-oxidative action, but as the amount of the formations increases, their beneficial effect wanes. They become a storage place for substances enhancing free radical processes, which makes them toxic themselves. It is such an approach to the primary causal factor for AD which lies at the roots of the new view on AD therapy, suggesting the use of methylene blue-based drugs, laser or intranasally applied insulin. A necessary condition, however, for these methods’ effectiveness is definitely an earlier diagnosis of the disease. Although there are numerous diagnostic methods for AD, their low specificity and high price, often accompanied by a considerable level of patient discomfort, make them unsuitable for early, prodromal screening. In this matter a promising method may be provided using an olfactory test, which is an inexpensive and non-invasive method and thus suitable for screening, although as a test of low specificity, it should be combined with other methods. Introducing new methods of AD treatment does not mean abandoning the traditional ones, based on enhancing cholinergic transmission. They are valuable as long as the therapy starts when abundant brain inclusions disturb the transmissions.
Authors and Affiliations
Eugenia Tęgowska, Adrianna Wosińska
Keywords
Related Articles
- EP ID EP66435
- DOI -
- Views 164
- Downloads 0
Inhibitors of microtubule polymerization- new natural compounds as potential anti-cancer drugs
Inhibitors of microtubule polymerization are compounds which, by binding to the tubulin dimer, prevent the normal course of cell division and lead to cell death. They cause inhibition of mitosis, affect the cytoskeleton...
Immunoregulatory action of melatonin. The mechanism of action and the effect on inflammatory cells
Literature data indicate a significant immunoregulatory role of melatonin. Melatonin exerts an effect directly affecting leucocytes bearing specific melatonin receptors or indirectly by means of melatonin regulating othe...
Metody badania autofagii oparte na przemianach białek MAP1LC3 i p62/SQSTM1
Autofagia jest procesem katabolicznym o fundamentalnym znaczeniu dla przetrwania okresów niedoborów składników odżywczych i w recyklingu organelli komórkowych. W ostatnim czasie obserwuje się bardzo znaczący wzrost zaint...
NKT cells: their development, mechanisms and effects of action
NKT cells are a heterogeneous subset of T lymphocytes that share surface markers and functional characteristics with both conventional T lymphocytes and natural killer cells. Most NKT cells express a semi-invariant T cel...
Właściwości reologiczne erytrocytów u pacjentów zakażonych Clostridium difficile