THE ROLE OF D-DIMER LEVELS AS A MARKER OF NEONATAL SEPSIS
Journal Title: GJRA-Global Journal For Research Analysis - Year 2019, Vol 8, Issue 6
Abstract
Sepsis is a major cause of neonatal morbidity and mortality. One complication of sepsis is coagulation dysfunction. Coagulation dysfunction is a complication of neonatal sepsis that can manifest clinically or subclinically in intravascular coagulation. D-dimer, a crosslinked brin degradation product, is increased in neonates with sepsis. A diagnostic study with cross-sectional design was conducted in October until December 2018 among 34 neonates with sepsis in the neonatology unit of General Hospital Center Haji Adam Malik Medan. In this study, D-dimer and blood culture were examined. A diagnostic test is to dene value of D-dimer sensitivity, specicity, positive predictive value, negative predictive value, positive likelihood ratio and negative likelihood ratio. There are 24 subjects with D-dimer levels <0.3 mg%. The sensitivity was 28%, specicity 70%, positive predictive value 40%, negative predictive value 58%, positive likelihood ratio 0.95 and negative likelihood ratio 1.02. D-dimer level is not a useful marker for neonatal sepsis.
Authors and Affiliations
Annette Regina Brahmana, Bugis Mardina Lubis, Muhammad Ali
Keywords
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