The role of fractalkine in the development of diabetic macular edema in patients with type 2 diabetes mellitus
Journal Title: Міжнародний ендокринологічний журнал - Year 2019, Vol 15, Issue 1
Abstract
Background. Diabetic macular edema (DME) is a severe complication of type 2 diabetes mellitus (DM) and a leading cause of vision loss in the working age population of most developed countries. The gold standard for DME treatment should be based on a good control of glycemia along with control of lipids and renal function. However, despite the systemic metabolic control values being essential for patients with diabetic retinopathy, it has proven to be insufficient for DME if it appears. In these patients, additional measures are needed in order to avoid the subsequent loss of vision. The aim of the work was to assess the content of blood fractalkine in patients with type 2 DM and DME in conjunction with the indicators of the thickness of the macula layers. Materials and methods. The study involved 82 patients with type 2 DM (145 eyes), divided into 4 groups in accordance with the DME form. The average age of patients was 65.25 ± 10.85 years, the average duration of DM — 14.00 ± 7.05 years, the average level of HbA1c — 8.40 ± 1.58 %. Results. Using analysis of variance and regression analysis, methods for constructing logistic regression models, we have shown that fractalkine is not associated with the risk of not low values (> QI) of nerve fiber layer, ganglion cell layer, inner plexiform layer, central sector of macula, thickness of fovea. Conclusions. Fractalkine may be a promising new therapeutic method for the treatment of diabetic retinal diseases. DME tends to be a chronic disease, although spontaneous recovery is not uncommon. It is important to recognize that 35 % of patients with macular edema had spontaneous resolution after 6 months if untreated.
Authors and Affiliations
M. L. Kyryliuk, S. А. Suk, S. O. Rykov, S. Yu. Mogilevskyy
Keywords
Related Articles
- EP ID EP535819
- DOI 10.22141/2224-0721.15.1.2019.158686
- Views 57
- Downloads 0
State of Indicators of Apoptosis and Angiogenesis Processes in Patients with Inactive Pituitary Adenomas
In the article, the authors analyze data from 71 patients with inactive pituitary adenomas (IPA) aged 18 to 70 years. The absence of correlation between the decline in eNOS enzyme activity and parameters of pro- and anti...
Features of Some Hormonal Parameters in Patients with Perinatal Losses
The presence of mixed urogenital infections during pregnancy leads to violations in mother’s body: changes of homeostasis, depression of the immune response, induction of the autoimmune processes resulting in reduced res...
Assessment of Efficacy of NPH Insulin in Cartridges Injection Technique
No abstract
From Epidemy of Obesity to Epidemy of Diabetes Mellitus
.
Polycystic Ovary Syndrome: Laboratory Diagnosis of Hyperandrogenic Status of a Woman (A Review of the Article «The Polycystic Ovary Syndrome: a Position Statement from the European Society of Endocrinology», October 2014)
The article presents the modern laboratory aspects for evaluation of hyperandrogenism according to published in October 2014 document of the European Society of Endocrinology in the diagnosis and treatment of polycystic...