The Role of Glycogen Synthase Kinase 3 Beta in Neuroinflammation and Pain
Journal Title: Journal of Pharmaceutics & Pharmacology - Year 2013, Vol 1, Issue 1
Abstract
Neuroinflammation is a crucial mechanism related to many neurological diseases. Extensive studies in recent years have indicated that dysregulation of Glycogen Synthase Kinase 3 Beta (GSK3β) contributes to the development and progression of these disorders through regulating the neuroinflammation processes. Inhibitors of GSK3β have been shown to be beneficial in many neuroinflammatory disease models including Alzheimer’s disease, multiple sclerosis and AIDS dementia complex. Glial activation and elevated pro-inflammation cytokines (signs of neuroinflammation) in the spinal cord have been widely recognized as a pivotal mechanism underlying the development and maintenance of many types of pathological pain. The role of GSK3β in the pathogenesis of pain has recently emerged. In this review, we will first assess the GSK3β structure, regulation, and mechanisms by which GSK3β regulates inflammation. We will then describe neuroinflammation in general and in specific types of neurological diseases and the potential beneficial effects induced byinhibiting GSK3β. Finally, we will provide new evidence linking aberrant levels of GSK3β in the development of pathological pain.
Authors and Affiliations
Han-Rong Weng
Keywords
Related Articles
- EP ID EP197857
- DOI 10.13188/2327-204X.1000001
- Views 95
- Downloads 0
The Role of Glycogen Synthase Kinase 3 Beta in Neuroinflammation and Pain
Neuroinflammation is a crucial mechanism related to many neurological diseases. Extensive studies in recent years have indicated that dysregulation of Glycogen Synthase Kinase 3 Beta (GSK3β) contributes to the developmen...
Three Examples Illustrating the Good Performance of an Advanced Mathematical Modeling Method Based on the Theory of Dynamic Systems in Pharmacokinetics
The objective of the current study is to give three examples illustrating the good performance of an advanced mathematical modeling method based on the theory of dynamic systems in pharmacokinetics. The performance of th...
NMDA Receptor Antagonism by Phencyclidine Reduces NWASP and WAVE1 Protein Expression and Reduces Levels of Myelination Markers in the Prefrontal Cortex of Rats
N-methyl-D-aspartate (NMDA) receptor antagonism by perinatal phencyclidine (PCP) treatment leads to neuronal damage and causes long-term behavioural alterations in rodents. It is routinely used to model pathological proc...
Current Medication Trends and Global Impact on Neurodegenerative Disorders
Neurodegenerative disorders are the medical condition characterized by destruction in neuronal cells, abruption of neuronal activity and distinct involvement of the functional movement. The main neuronal disorders like P...
Modeling and Simulation of Intracellular Drug Transport and Disposition Pathways with Virtual Cell
The development of computational approaches for modeling the spatiotemporal dynamics of intracellular, small molecule drug concentrations has become an increasingly important area of pharmaceutical research. For systems...