The role of hyaluronic acid in selected diseases
Journal Title: Medycyna Sportowa - Year 2018, Vol 34, Issue 4
Abstract
Hyaluronic acid (HA) is a polysaccharide (glycosaminoglycan), which is normally present in all living organisms. Its chemical constitution is identical in mammals and bacteria. This mucopolisaccharide chain may consist of even several thousands of saccharide subunits. The unique, highly elastic nature of HA, together with its bio-compatibility and the lack of immunogenic potential in relation to the human body, have contributed to the widespread use of this substance in many clinical solutions including supplementation of the synovial fluid in patients with joint inflammation as an adjuvant agent in ophthalmic and dental surgery and the preparation accelerating postoperative wound healing. Recent studies assess the properties of HA, a potential drug carrier in various applications including eye drops, inhalations, parenteral and local application and as a carrier for oncological agents. The aim of the study based on the analysis of available literature was to explain the construction, metabolism and potential of HA application in the treatment of selected disease units, including orthopedic and oncological conditions.<br/><br/>
Authors and Affiliations
Katarzyna Malinowska, Alicja Klimczak, Marcin Możdżan, Roman Modranka, Karolina Śmigiel, Paweł Piątkowski, Anna Merecz-Sadowska, Łukasz Skowerski, Radosław Zajdel, Tetiana Levadna, Hanna Zielińska-Bliźniewska, Wiesław Tomaszewski
Keywords
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