The Role of Inflammatory Mediators in the Pathogenesis of Alzheimer’s Disease
Journal Title: Sultan Qaboos University Medical Journal - Year 2015, Vol 15, Issue 3
Abstract
Alzheimer’s disease (AD), a neurodegenerative disorder associated with advanced age, is the most common cause of dementia globally. AD is characterised by cognitive dysfunction, deposition of amyloid plaques, neurofbrillary tangles and neuro-inflammation. Inflammation of the brain is a key pathological hallmark of AD. Tus, clinical and immunopathological evidence of AD could be potentially supported by inflammatory mediators, including cytokines, chemokines, the complement system, acute phase proteins and oxidative mediators. In particular, oxidative mediators may actively contribute to the progression of AD and on-going inflammation in the brain. Tis review provides an overview of the functions and activities of inflammatory mediators in AD. An improved understanding of inflammatory processes and their role in AD is needed to improve therapeutic research aims in the feld of AD and similar diseases.
Authors and Affiliations
Gholamreza Azizi| Department of Laboratory Medicine, Imam Hassan Mojtaba Hospital, Alborz University of Medical Sciences, Karaj, Iran, Research Center for Immunodefciencies, Children’s Medical Center, Shadi S. Navabi| Department of Immunology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran, Ahmed Al-Shukaili| Health & Social Services Sector, Te Research Council Oman, Muscat, Oman, Mir H. Seyedzadeh| Department of Immunology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran, Reza Yazdani| Research Center for Immunodefciencies, Children’s Medical Center, Department of Immunology, Faculty of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran, Abbas Mirshafey| Department of Immunology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
Keywords
Related Articles
- EP ID EP14576
- DOI -
- Views 334
- Downloads 14
Chloroquine-induced Acute Dystonic Reactions after a Standard Therapeutic Dose for Uncomplicated Malaria
Acute dystonic reactions (ADR) are extrapyramidal effects that usually occur after the initiation of a wide variety of drugs or triggering factors besides neuroleptics. We report the case of a 54-year-old man who was...
Round Cell Vaginal Malignant Melanoma A rare entity
Malignant melanoma is predominantly a skin disease but in rare instances it may occur at other sites. A vaginal melanoma is a rare clinical entity and the round cell type is an uncommon variant. Although the present ca...
Histological Evaluation of Hydroxyapatite Granules with and without Platelet-Rich Plasma versus an Autologous Bone Graft Comparative study of biomaterials used for spinal fusion in a New Zealand white rabbit model
Objectives: Hydroxyapatite (HA) has osteoconductive properties and is widely used as a bone graft substitute. Platelet-rich plasma (PRP) is an autologous product with osteoinductive effects. Hypothetically, a combinat...
Intra-Operative Neural Response Telemetry and Acoustic Reflex Assessment using an Advance-In-Stylet Technique and Modiolus-Hugging A prospective cohort study
Objectives: Te development of cochlear implant (CI) electrode arrays has focused on the use of a minimally invasive technique involving a modiolus-hugging placement of the electrode. Te aim of this study was to evaluat...
Mechanical Prosthetic Valves and Pregnancy A therapeutic dilemma of anticoagulation
Choosing the best anticoagulant therapy for a pregnant patient with a mechanical prosthetic valve is controversial and the published international guidelines contain no clear-cut consensus on the best approach. Tis is...