The role of interleukin-1 family of cytokines in nociceptive transmission
Journal Title: BÓL - Year 2014, Vol 15, Issue 4
Abstract
IL-1 family of cytokines, is a group of several proteins which are involved in regulation of immuneresponse. It has been shown that members of that family , especially: IL-1α, IL -1β, IL-18 and IL-33 act asmediators in nociceptive transmission and play a crucial role in pathogenesis of multiple diseases. Thediscovery of IL-1Ra, naturally occurring antagonist of I L-1 receptor (IL-1RI i IL-1RII) and IL-18 binding protein has led to many studies involving use of recombinant receptor antagonist in pain therapy or in treatment of such a diseases as: rheumatoid arthritis, multiple sclerosis, skin diseases or diabetes.
Authors and Affiliations
Dominika Piłat, Joanna Mika
Keywords
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