The role of magnetization transfer MRI in the evaluation of brain and in the diagnosis of brain diseases in pediatrics
Journal Title: Ege Tıp Dergisi - Year 2017, Vol 56, Issue 1
Abstract
Aim: It is aimed to evaluate the contribution of Magnetization Transfer (MT) to conventional magnetic resonance imaging in pediatric central nervous system pathologies, and to present the MT findings and the changes in Magnetization Transfer Ratio (MTR) with age in normal pediatric cases. Materials and Methods: A total of 126 pediatric patients (48 girls and 78 boys), who presented to our hospital with various neurological complaints, were divided into two different age groups: 28 infants (1 month-2 years) and 98 children (2-18 years). They underwent conventional and MT MRI examinations. T-test, correlation analysis and variance analysis were used for statistical evaluation of data of the cases in the normal group. Results: No statistically significant difference was found in the MTR of 66 normal cases (36 boys and 30 girls) in 18 anatomical locations between the genders. Correlation analysis performed in normal cases revealed that increased MTR was significantly correlated with increasing age, excluding the MTR of thalamus, in all age groups (28 cases were between 0 and 24 months of age, 26 were between 24 and 108 months of age, and 12 were between 109 and 192 months old). Among grey matter structures, the highest MTR was observed in globus pallidus, dentate nucleus and nucleus ruber. In the comparison of the cases with neurometabolic and neurodegenerative diseases and CNS pathologies such as infections and tumors, diagnosed based on clinical examination and conventional MRI, with age-matched normal cases, demonstrated lower MTR in the areas involved. Conclusion: It is thought that MT imaging, which is yet not available in routine practice, is helpful in diagnosis not alone but together with other MRI sequences.
Authors and Affiliations
Elçin Aydın, CENK ERASLAN, Pelin Yüzbaş, Nuri Şener
Keywords
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- EP ID EP336154
- DOI 10.19161/etd.344292
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