The role of neuropsychological assessment in the detection of early symptoms in frontotemporal dementia and parkinsonism linked to chromosome 17 (FTDP-17)
Journal Title: Acta Neuropsychologica - Year 2011, Vol 9, Issue 2
Abstract
Frontotemporal dementia and parkinsonism linked to chromosome 17 is a rare variant of frontotemporal dementia, characterized by behavioral, cognitive and motor dysfunctions. The onset of the disease is variable. However, cognitive and behavioral changes usually precede motor symptoms. Early abnormalities can be identified by means of smell tests, motor speech assessment and neuropsychological evaluation. We provide a clinical description of a 48-year-old man with a P301L MAPT mutation, who presented with subtle neuropsychological deficits and depression, without behavioral or motor changes when diagnosed with FTDP-17. The results of two neuropsychological assessments (baseline and follow-up) are presented, addressing both global and specific cognitive functions. The results showed early phonemic fluency deficits, followed by language and procedural memory impairment. In addition, the qualitative analysis of the Rey/ Taylor Complex Figure Test and picture description trials (both oral and written) provided further evidence for cognitive dysfunction in this patient. Early verbal fluency deterioration, possibly linked to both executive dysfunction and language breakdown, is consistent with previous reports. Our data suggests that a comprehensive neuropsychological assessment in individuals with FTDP-17 is highly recommended and should include both quantitative and qualitative measures.
Authors and Affiliations
Emilia Sitek, Anna Barczak, Ewa Narożańska, Małgorzata Chodakowska-Żebrowska, Barbara Jasińska-Myga, Bogna Brockhuis, Mariusz Berdyński, Dariusz Wieczorek, Cezary Żekanowski, Seweryna Konieczna, Maria Barcikowska, Zbigniew Wszołek, Jarosław Sławek
Keywords
Related Articles
- EP ID EP55373
- DOI -
- Views 97
- Downloads 0
RELATIONSHIP BETWEEN THE VERBAL FLUENCY AND ACADEMIC ACHIEVEMENT IN SECOND AND THIRD GRADE STUDENTS: THE EFFECTS OF GENDER AND PARENTS’ EDUCATIONAL LEVEL
Verbal fluency is an important skill related to academic success. Many studies have indicated a strong link between verbal fluency and cognitive processes. The exact nature and size of the relationship between verbal flu...
FRONTAL LOBE REGULATORY CONTROL MECHANISMS: EVIDENCE FOR DIMINISHED FRONTAL EYE FIELD CAPACITY IN HOSTILE VIOLENCE-PRONE MEN
Background: The experiment was designed to test the relationship between self-reported hostility and the capacity of frontal eye field regulatory control over visual smooth pursuit eye movements. Previous research has de...
MEDIATORS OF RELATIONSHIPS BETWEEN PROCRASTINATION AND NEUROTICISM
Background: Procrastination means delaying action, which creates serious problems both in academic, work, and clinical settings since it leads to reduced performance levels, and gives rise to psychological distress resul...
INDIVIDUAL HAPPINESS IN TERMS OF PROCESS NEUROPSYCHOLOGY
[b][/b][b]Background. [/b]The aim of this work was to discover what happiness means to a sample of healthy persons as compared to persons with brain and spinal injury resulting from an automobile accident. [b]Material/Me...
THE QUALITY OF LIFE OF THE PARENTS OF A CHILD WITH RUBINSTEIN-TAYBI SYNDROME
The goal of our study was to examine the functioning of a family with a child who has Rubenstein-Taybi syndrome (RSTS) in respect to the quality of life (QOL) of the child’s parents. We used measures associated with the...