The Role of Ormeloxifene in the Management of Dysfunctional Uterine Bleeding: A Prospective Clinical Study
Journal Title: International Journal of Contemporary Medical Research - Year 2018, Vol 5, Issue 1
Abstract
Introduction: The term dysfunctional uterine bleeding (DUB) is used for abnormal uterine bleeding occurring in the absence of identifiable pathology. A number of drugs are available for management of DUB – nonsteroidal anti-inflammatory drugs (NSAIDs), tranexamic acid, ethamsylate, hormones like OCP, progestins etc. The present study was done to determine the efficacy and safety of Ormeloxifene in the management of DUB. Material and Methods: This prospective clinical study involved 75 patients with DUB who were treated with Ormeloxifene 60 mg tablet twice a week for first 12 weeks and then once a week for next 12 weeks. They were followed up at 4th, 8th, 12th and 24th week of treatment. The outcome was studied by assessment of menstrual blood loss by PBAC score, Hb level in g/dl, endometrial thickness in mm, relief of dysmenorrhoea and any side effects of drugs. Paired T Test and Wilcoxon signed rank test was used to see the effect of drug. Results: The median PBAC score was significantly reduced from 265 to 27 after 6 months (P<0.001). The mean hemoglobin concentration was significantly increased from 9.15 g/dl to 10.36 g/dl at 6 months (P<0.001). The mean endometrial thickness was reduced from 11.81 mm to 7.63mm after 6 months (P<0.001). 84% women showed marked subjective improvement in symptoms. There were no major side effects of the drug. Conclusion: Ormeloxifene, with its convenient dose schedule, is an effective and safe alternative in the management of dysfunctional uterine bleeding.
Authors and Affiliations
Archana Kumari, Ritika Prakash
Keywords
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