The Role of Serotonin in the Regulation of Motor Function of the Upper Digestive Tract in Normal and Pathological Conditions

Journal Title: Biomedical Journal of Scientific & Technical Research (BJSTR) - Year 2019, Vol 19, Issue 3

Abstract

In the esophagus and stomach, serotonin is present in the neurons of the enteric nervous system and extraorgan serotonergic neurons and fibers [1-4], which regulate the motor function of these organs. In addition, serotonin is contained in platelets, mast cells and macrophages and may appear extracellularly under conditions of pathology. It is important to investigate the effect of serotonin on the motor function of hollow organs, both in functional conditions and in pathology. The aim is to investigate the role of serotonin in the regulation of motor function of the esophagus and stomach in functional conditions and in the simulation of gastroesophageal reflux (GER). Materials and methods. The experiments were carried out on 32 Wistar rats weighing 240-270 g under nebutal anesthesia (40 mg / kg intraperitoneally). An upper median laparotomy was carried out, bipolar silver electrodes were applied to the cardiac section of the stomach and the lower third of the esophagus to record the electromyogram (EMG). Serotonin adipinate was administered at a dose of 100 mg / kg intravenously and its effect on the motor function of the esophagus and stomach of group 1 animals was examined (n = 16). The GER model was created by injecting 0.1 ml of methylene blue into the cardiac section of the stomach and administering serotonin to animals of the 2nd group against this background (n = 16). It was noted staining of the lower third of the esophagus, indicating the development of GER. Slow-wavelength EMG activity and power of tonic contractions were recorded. Statistical processing was carried out using the software package Statistica-17. Results. The frequency of slow waves of the esophagus with the introduction of serotonin was 19.0 ± 4.0 to 23.0 ± 4.5 / min (an increase of 21.1% p <0.05), the amplitude from 0.15 ± 0.02 to 0,18 ± 0.03 mV (increase by 20% p <0.05), power of tonic contractions from 2.85 ± 0.21 to 4.14 ± 0.33 (increase by 43.9% p <0.05). The frequency of slow gastric waves with the introduction of serotonin increased from 9.1 ± 0.3 to 11.3 ± 0.6 / min (an increase of 24.2% p <0.05), the amplitude from 0.12 ± 0.03 to 0.22 ± 0.04 mV (increase by 83.3% p <0.05), power of tonic contractions from 1.092 ± 0.21 to 2.486 ± 0.33 (increase by 127.6% p <0.05) . Thus, the introduction of serotonin leads to a pronounced stimulatory effect on the motor function of the esophagus and stomach. The introduction of methylene blue followed by the introduction of serotonin changed the frequency of slow waves of the lower third of the esophagus — it increased 1.8 times (p <0.01), amplitudes 1.1 times (p <0.01), the power of tonic contractions was 3.893 ± 0.23 (an increase by 35.5% p <0.05). Thus, the introduction of methylene blue, as a donor of nitric oxide, leads to relaxation of the lower esophageal sphincter. The subsequent activation of retrograde motor activity of the smooth muscles of the stomach by serotonin leads to the development of GER. Findings. The study showed that serotonin stimulates the motor function of the esophagus and stomach in both antegrade and retrograde directions. Serotonin has a pronounced effect on the development of GER.

Authors and Affiliations

Puzikov AM

Keywords

Related Articles

Fine structure of Somatotrophs in Pars Distalis of the Indian wild Caught Female Bat, Taphozous nudiventris kachhensis (Dobson)

The ultra structural observations on Somatotrophs During estrus cells are spherical to oval in shape with the spherical nucleus. Cytoplasm of cell is filled with a large number of round to oval shaped secretory granules...

Reliability and Concurrent Validity of the BruininksOseretsky Test in Children with Cerebral Palsy

Background: The Bruininks-Oseretsky test (BOT2) assesses global and fine motor proficiency in healthy children. We evaluated concurrent validity and reliability of the short form (BOT2-SF) and the upper-limb items of the...

The Challenge of Introducing Point of Care Diagnostics in Farm Animal Health Management

Point of Care (POC) diagnostics are analytical devices and other rapid tests which provide fast clinical information that can be directly assessed on-site. They often require laboratory confirmation; however, they are in...

Overall Management of Individualized Treatment for a Patient with Advanced NSCLC

Objective: This article analyzes the overall management of a patient with advanced non-small cell lung cancer who has been managed for a total of 4 years and provides a reference for clinical case management. Methods: A...

Metabolic Surgery for Tackling Type II Diabetes Epidemic

Type II Diabetes is a serious chronic metabolic dysfunction leading to increased morbidity, mortality and cost. Globally an estimated 422 million adults were living with diabetes in 2014, compared to 108 million in 1980....

Download PDF file
  • EP ID EP620617
  • DOI 10.26717/BJSTR.2019.19.003312
  • Views 215
  • Downloads 0

How To Cite

Puzikov AM (2019). The Role of Serotonin in the Regulation of Motor Function of the Upper Digestive Tract in Normal and Pathological Conditions. Biomedical Journal of Scientific & Technical Research (BJSTR), 19(3), 4375-4376. https://europub.co.uk/articles/-A-620617