The Role of Smoking in the Development of Psoriatic Arthritis and Psoriasis
Journal Title: Біль. Суглоби. Хребет - Year 2016, Vol 3, Issue 23
Abstract
The paper covers the new data on smoking effects on the development of psoriasis and psoriatic arthritis. It was found that smoking aggravates the severity of psoriasis, worsens the prognosis, and makes the smoking patients less sensitive to treatment. Pathogenic links indicate that smoke induces oxidative damage, promotes inflammatory changes and increases the expression of genes associated with psoriasis. In addition, nicotine binds acetylcholine receptors on dendritic cells, macrophages, endothelial cells, and keratinocytes. This leads to inflammation and immune stimulation of Th1-cells and later severe leukocyte migration to skin due to the increased expression of intercellular adhesion molecule‑1 and vascular adhesion molecule‑1 on endothelial cells; to the increased angiogenesis and uncontrolled keratinocyte proliferation as well. Information about the genetic predisposition to the development of arthritis and psoriasis, and the role of smoking in the modification of genetic factors is provided. Smoking causes a specific metabolic and genetic psoriasis and psoriatic arthritis comorbidity, which determines the frequency of diseases flare, its severity and complications. Currently, physicians can prevent exacerbation of smoking-related diseases such as psoriasis and psoriatic arthritis by persuading their patients to quit smoking.
Authors and Affiliations
I. Yu. Golovach
Keywords
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- EP ID EP209512
- DOI 10.22141/2224-1507.3.23.2016.85006
- Views 133
- Downloads 0
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