The role of Th1 and Th2 cytokines among women with recurrent spontaneous miscarriage

Journal Title: Scientific Journal of Medical Science - Year 2014, Vol 3, Issue 7

Abstract

The objective of this study was to compare the concentrations of Th1 (IFN-γ , TNF-α) and Th2 (IL-4,IL-10) cytokines in the serum of normal pregnant and recurrent spontaneous abortion (RSA) women in 1st trimester as well as in the normal fertile non pregnant women. In RSA women there was a significant increasing in the mean concentration of Th1 cytokines (TNF- α and IFN- γ) as well as in Th1/TH2 than normal pregnant and non pregnant women. In normal pregnant women there was significant increasing in the mean concentration of Th2 cytokines (IL-4 and IL-10). RSA was associated with increasing concentration of Th1 cytokines while successful pregnancy was associated with increase concentration of Th2 cytokines in the first trimester of pregnancy, indicating Th2 bias in normal pregnancy and a Th1 –bias in unexplained RSA.

Authors and Affiliations

M. Sharief*| Department of Gynecology & Obstetrics, College of Medicine., R. Mohammed| Department of Biology, College of Science, University of Basrah, Basrah, Iraq., W. S. Shani| Department of Biology, College of Science, University of Basrah, Basrah, Iraq.

Keywords

Related Articles

Genetic mice models of Parkinson’s disease

The loss of dopaminergicneurons in the substancia nigra pars compacta leads to the characteristicsymptoms of Parkinson's disease (PD), whose Lewy bodies is a pathologic signalmost always found. Various monogenic forms ac...

Efficacy of music listening with conventional physiotherapy management on sub-acute stroke patients

Objective: The use of melody and rhythm has long been recommended for music-based treatment. Current study was to determine the effect of music listening additions to the conventional protocol that aim to enhance stroke...

Treatment of obesity: medical managements

Obesity is a very complex illness. It is one of the most prevalent diseases in the western world, its importance lies in the comorbidities that surround it, as well as the predisposition to cardiovascular events and othe...

Antenatal detection of congenital cytomegalovirus infection (a comparative study between serological and molecular identification of cytomegalovirus infection)

Cytomegalovirus, or CMV, is a common virus that infects most people worldwide. CMV infection is usually harmless and rarely causes illness. A healthy immune system can hold the virus in check. However, if a person's immu...

A critical review on the efficacy of integrated child development service scheme with concern to growth progressions in early childhood

A growing body of evidence suggests that supplementary feeding programs have a positive effect on reducing malnutrition prevalence in developing countries. In India, despite substantial funding of its early childhood dev...

Download PDF file
  • EP ID EP1273
  • DOI 10.14196/sjms.v3.i7.1514
  • Views 445
  • Downloads 39

How To Cite

M. Sharief*, R. Mohammed, W. S. Shani (2014). The role of Th1 and Th2 cytokines among women with recurrent spontaneous miscarriage. Scientific Journal of Medical Science, 3(7), 345-351. https://europub.co.uk/articles/-A-1273