The Role of Uric Acid in Carbohydrate Metabolism among Hypertensive Individuals
Journal Title: Haematology International Journal - Year 2018, Vol 2, Issue 1
Abstract
The association between fasting blood glucose and insulin and serum uric acid levels in general population, as well as the positive association between serum uric acid levels and development of type 2 diabetes mellitus have been reported. 1.1. Objective: Correlation of serum uric acid (SUA) levels with various parameters indicative of carbohydrate metabolism among treated and newly diagnosed, untreated hypertensive individuals. 1.2. Research Design and Methods: We studied 2803 hypertensive patients treated or newly diagnosed untreated. The levels of SUA and other parameters of carbohydrate metabolism, such as fasting glucose (gl0), fasting insulin levels (IN0), glycated hemoglobin (HbA1c), fasting insulin resistance index (HOMA0), loading insulin resistance index (HOMA120), fasting c-peptide (c-pept0) and loading c-peptide (c-pept120) were calculated. The study population was divided into two groups: group A (N=543): SUA levels above normal range and group B (N=2260): SUA levels within normal range. 1.3. Results: In the overall study population SUA levels showed a statistically significant positive correlation with gl0 (p <0.001), in0 (p<0.001), HbA1C (p=0.002) and HOMA0 (p<0.001), gl120 (p =0.003), in120 (p=0.007), HOMA120 (p=0.002) and c-pept0 (p<0.001). In the glucose loading subgroups SUA levels showed a statistically significant positive correlation with gl120 (r=0.142, p =0.003), in120 (r=0.119, p=0.007), HOMA120 (r=0.184, p=0.002) and c-pept0 (r=0.292, r<0.001). 1.4. Conclusion: The levels of SUA in hypertensive individuals are both associated with and dependent on different parameters of carbohydrate metabolism and insulin resistance, either suggesting a potential role of uric acid in the pathogenesis of metabolic syndrome and deranged glucose metabolism, or verifying that it constitutes an aspect of the underlying pathologic condition.
Authors and Affiliations
Karamanou G Alexandra
Keywords
Related Articles
- EP ID EP291046
- DOI -
- Views 95
- Downloads 0
Incidental Detection of Sickle Cell Anaemia as a Significant Haematological Problem in an Island Based Population
1.1. Introduction: Sickle cell anaemia is a haematological disease with a known gentic cause. However, there is paucity of data regarding this condition from islands of the world. Also there is no previous study in which...
Management of Adult Onset Familial Hemophagocytic Lymphohistiocytosis (FHL): A Dilemma
Background: Perforin gene (PRF1) mutations cause the familial form of hemophagocytic lymphohistiocytosis (HLH). Case presentation: Here, we report a 36-year-old male with familial HLH, who was initially thought to be se...
Surface and Interacellular Targets of Acute Myeloid Leukemia Therapy Detectable at Leukemic Stem Cell level
For over 50 years investigators have considered a malignant stem cell as the potential origin of and a key therapeutic target for acute myeloid leukaemia (AML) and other forms of cancer [1]. Leukaemic stem cells (LSCs) h...
Fatal Case of Haemophagocytic Syndrome Associated With Infection of Plasmodium Falciparum
Haemophagocytic lymphohistiocytosis (HLH) is a hyperinflammatory condition which can occur as a primary syndrome (genetic in origin) or arise secondary to infectious, rheumatologic, malignant or metabolic disorders. HLH...
Environmental Factors as Determinants of Severity of SCD in Nigeria
Sickle cell anaemia (SCA) is a chronic blood disorder characterized by red blood cells that assume an abnormal sickle shape when deoxygenated and may block different areas of the microcirculation causing ischaemia in var...