The Role of Vitamin D on Levels of Oxidative Stress and Inflammatory Factors in Patients with Multiple Sclerosis
Journal Title: مجله علمي دانشگاه علوم پزشكي كردستان - Year 2018, Vol 23, Issue 96
Abstract
Background and Aim: Multiple sclerosis (MS) is an inflammatory and autoimmune disease characterized by the degeneration of myelin sheath in the central nervous system. Vitamin D deficiency and an increase in the levels of oxidative stress and inflammation are regarded as possible causes of the disease. This review article deals with the role of vitamin D on the levels of oxidative stress and inflammatory factors in the patients with multiple sclerosis. Material and Method: In this review study data were selectively collected by using google scholar, science direct and pubmed data bases and also by searching key words of MS, vitamin D, inflammatory factors and oxidative stress, from 1990 to 2018. Results: Various studies have shown increased levels of pre-inflammatory factors and decreased levels of anti-inflammatory factors in the serum of the patients with MS. Therefore, active form of vitamin D, 1.25 (OH) 2D3 (calcitriol), can be effective in regulation of cellular immune function. It can decrease production of inflammatory cytokines and oxidative stress but, increases anti-inflammatory cytokines. This vitamin can affect energy metabolism and its deficiency can result in increased basal metabolic rate and lack of provision of sufficient energy to the energy-dependent neurons. Conclusion: The results of this study showed that vitamin D can play a two-way role in maintaining balance between inflammatory and anti-inflammatory cytokines. Vitamin D can improve survival of the MS patients by its antioxidant effect and reduction of oxidative stress.
Authors and Affiliations
Hadi Bazyar, Fatemeh Haidari, Majid Mohammad Shahi
Keywords
Related Articles
- EP ID EP538257
- DOI -
- Views 73
- Downloads 0
XML Expression of aap and icaR genes involved in biofilm production in clinical strains of Staphylococcus aureus resistant to methicillin and gentamicin
Backgrounds and Aim: Staphylococcus aureus biofilms are involved in a multitude of serious chronic infections. Production of biofilms is a defensive-invasive process controlled and regulated by the aap and icaR genes. Th...
Effect of prenatal immobilization stress on spatial memory, anxiety-like behavior and brain BDNF concentration in the F1 generation male mice
Background and Aim: In this study, we investigated the effect of immobilization stress during pregnancy on the spatial memory, anxiety-like behavior and brain BDNF level in F1 generation male NMRI mice. Materials and Met...
The protective effects of Tanacetum parthenium extract on CCl4-induced myocardium injury in rats
Background and Aim: The aim of this study was to investigate the protective effects of Tanacetum parthenium extract (TPE) on lipid peroxidation and acute heart injury induced by carbon tetrachloride (CCl4) in rats. Mater...
Investigation of the effect of Ginkgo biloba leaf extract on spatial memory impairment and hippocampal neuronal loss caused by diabetes induced by streptozotocin in rats
Background and Aim: Learning and memory defect occurs following chronic diabetes with uncontrolled blood glucose. Ginkgo leaf extract improves brain blood flow. Also it contains antioxidant components and has shown benef...
Concentrations of homocysteine and CRP after 8 weeks of resistance training circle with different rest intervals
Background and Aim: Resistance training exercise is one of the most common methods in fitness programs and health programs for athletes and therapists. Manipulation of every variable of training, such as rest intervals c...