The role of YKL-40 in a cancerous process

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The role of YKL-40 in a cancerous process

Journal Title: Advances in Hygiene and Experimental Medicine - Year 2016, Vol 70, Issue

Abstract

YKL-40 is a secretory protein secreted among others by tumor cells and tumor-associated macrophages. Due to the structural homology this protein was classified to chitinases family CLP (chitinase – like protein) and to 18 of glycosyl hydrolase family, but it has no catalytic function. Elevated levels of YKL-40 in serum is observed in the inflammatory diseases of various aetiology and in cancers, such as breast, ovarian, colon or lung. The results of many studies suggest a significant relationship of YKL-40 with progression of cancer: incidence of metastases, shorter relapse-free survival and shorter overall survival. It is believed that YKL-40 may be a prognostic factor of cancer development and the patient’s response to the applied therapy. Elevated levels of protein in serum of cancer patients may play a role in angiogenesis, proliferation and migration of tumor cells. Probably the mechanism of this phenomenon is the result of YKL-40 action by FAK and PI3K/AKT signaling pathways. Results obtained so far are largely based on an analysis of the YKL-40 level in the patients’ serum and on the assessment of changes in the expression level of this protein in studies in vitro and in vivo.

Authors and Affiliations

Agnieszka Rusak, Karolina Jabłońska, Piotr Dzięgiel

Keywords

YKL-40 nowotwory czynnik prognostyczny YKL-40 cancers prognostic factor

EP ID EP206099
DOI -
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