The Specific Role of Periodontal Disease in Lung Cancer Pathogenesis
Journal Title: Modern Approaches in Dentistry and Oral Health Care - Year 2018, Vol 1, Issue 2
Abstract
It has been proposed that poor oral hygiene, especially in high risk patients could be a predatory factor for respiratory diseases. Oral cavity that coincides with trachea could be a natural gate for colonization by respiratory pathogens. Dental plaque can be colonized by those that have been inhaled from the oro pharynx cavity to the upper airways and then can approach the lower airway and adhere to the bronchial or alveolar epithelium [1,2]. Periodontal Disease (PD) has been associated with chronic lung diseases, such as Chronic Obstructive Pulmonary Disease (COPD) [3,4]. It has also been recorded that pulmonary function in COPD patient’s decreases with increasing Clinical Attachment Loss (CAL), and an association between poor oral hygiene and COPD was recorded after controlling for potential confounders, such as gender, age, smoking andsocio-economic level [5]. The mentioned findings were in accordance with those that carried out from previous casecontrol and prospective studies [6-10]. However, only one similar investigation has not confirmed such observations [11]. Epidemiological researches have investigated the association between COPD and lung cancer (LC) [12-14]. Cigarette smoking is the principle risk factor for developing COPD [15] and LC [12-16]. Smokers with COPD are at a higher risk of developing LC, suggesting that an association exists between the processes that causes both diseases [17,18]. However, the majority of smokers do not develop COPD or LC despite the fact that the accumulated smoking history increases the risk of developing PD and cancer [17-20]. The contribution of smoking to PD development requires poor oral hygiene whereas in cases of established PD, smoking accelerates its progression. Similarly, smoking consists an important risk factor for LC development, however does not cause the disease to all smokers [21].
Authors and Affiliations
Nikolaos Andreas Chrysanthakopoulos
Keywords
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- EP ID EP600170
- DOI 10.32474/MADOHC.2018.01.000108
- Views 76
- Downloads 0
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