The Values of First-trimester Maternal Serum Markers in Predicting Poor Obstetric Outcomes

Journal Title: Istanbul Medical Journal - Year 2019, Vol 20, Issue 4

Abstract

Introduction: The effects of pregnancy-associated plasma protein A (PAPP-A) and maternal serum free beta-human chorionic gonadotropin (β-hCG), which are first trimester maternal serum markers, on assisting in the diagnosis of chromosomal abnormalities and perinatal outcome are discussed. The aim of the presented study was to investigate the predictive value of first-trimester PAPP-A and β-hCG) levels in predicting poor obstetric outcomes. Methods: A total of 549 patients who underwent first trimester screening in Perinatalogy Outpatient Clinic of our hospital between January 2016 and March 2018 were included in this study. Patients with crown-rump length (CRL) measurements in the range of 45-84 mm, patients with singleton pregnancy and patients who delivered at 24 weeks or later were included in the study. CRL, nuchal translucency, mean uterine artery pulsatility index, PAPP-A and free β-hCG levels were recorded. The 5th and 10th percentile values of PAPP-A and free β-hCG levels were designated according to the literature. Results: There was no difference between PAPP-A percentile groups in terms of mean birth weight or gestational age at delivery. However, mean gestational age at delivery was lower in patients with free β-hCG levels below 10th percentile. Preterm delivery was significantly higher in the group with PAPP-A levels below 5th percentile (p=0.049). Also, preeclampsia (PE) was higher in the group with free β-hCG below 10th percentile (p=0.003). Conclusion: The risk poor obstetric outcome such as preterm delivery, low birth weight and PE may be associated with low PAPP-A and free β-hCG levels. However, further studies are needed to explain the relationship between first trimester screening markers and neonatal outcomes.

Authors and Affiliations

Şafak Yılmaz Baran, Hakan Kalaycı, Gülşen Doğan Durdağ, Seda Yüksel Şimşek, Selçuk Yetkinel, Erhan Şimşek

Keywords

Related Articles

Non-operating Room Anaesthesia Practices in an Endoscopy Unit at a Tertiary Centre: A Retrospective Evaluation

Introduction: In recent years, gastrointestinal endoscopic procedures have been performed with sedo-analgesia at many centres. We aimed to present a 1-year retrospective analysis of non-operating room anaesthesia (NORA)...

A Localized Painful Rash Induced by Linagliptin in a Patient with type 2 Diabetes

The number of patients with type 2 diabetes using dipeptidyl peptidase-4 (DPP-4) inhibitors is increasing across the world. Although this class of antidiabetic medications is generally safe and associated with less side...

Smoking is a Strong Independent Predictor of Acute Coronary Syndrome Among Patients with Coronary Artery Ectasia

Introduction: The independent relationship between smoking and Acute Coronary syndrome (ACS), among other risk factors, was investigated in patients with ectasic coronary arteries. Methods: Between June 2015 and August...

Preliminary Outcomes of Hip Arthroscopy in the Treatment of Femoroacetabular Impingement with Early Stage Osteoarthritis

Introduction: Femoroacetabular impingement (FAI) has been recognized as a risk factor of osteoarthrosis that causes a painful joint and decreased range of motion. Arthroscopic procedures were used for the treatment of FA...

Relationship between Mode of Delivery and Frequency and Treatment Outcomes of Congenital Nasolacrimal Dacryostenosis

Introduction: The present study evaluates the relationship between the mode of delivery and the frequency and treatment outcomes of congenital nasolacrimal duct obstruction (CNDO). Methods: The medical records of childr...

Download PDF file
  • EP ID EP675507
  • DOI 10.4274/imj.galenos.2019.90001
  • Views 133
  • Downloads 0

How To Cite

Şafak Yılmaz Baran, Hakan Kalaycı, Gülşen Doğan Durdağ, Seda Yüksel Şimşek, Selçuk Yetkinel, Erhan Şimşek (2019). The Values of First-trimester Maternal Serum Markers in Predicting Poor Obstetric Outcomes. Istanbul Medical Journal, 20(4), -. https://europub.co.uk/articles/-A-675507