THERAPEUTIC EFFECT OF BELLAMYA BENGALENSIS LAMARCK BY INHIBITION OF OXIDATIVE STRESS IN EXPERIMENTAL ARTHRITIC MODEL
Journal Title: International Journal of Pharmaceutical Sciences and Research (IJPSR) - Year 2019, Vol 10, Issue 6
Abstract
Objective: Oxidative stress and generation of free radicals leads to several chronic inflammatory diseases like arthritis, diabetes mellitus, cancer, etc. Arthritis is an immune-mediated systemic disorder known to impair the quality of life. In spite of development of drug discovery, therapeutic targeting of arthritis is still not satisfactory. Bellamya bengalensis has been long known for used in ailments like arthritis, asthma, conjunctivitis in traditional medicine. There are very few studies for clarification of scientific understanding of these therapies. In the present study, a purified fraction of Bellamya bengalensis mass (PBB) was assessed for oxidative stress in arthritis in Wistar rats. Methods: Arthritis was induced by 0.1 ml of Freund’s complete adjuvant (FCA) in the left hind paw of Wistar rats. After that, PBB was administered orally at 100 mg/kg, 200 mg/kg and 400 mg/kg doses for consecutive 28 days. A thorough investigation of serum and tissue parameters, including autopsied histopathological analysis, related to systemic dysfunction due to oxidative stress during arthritis were evaluated at the end of the study. Results: FCA generates a cascade of free radicals, oxidative stress, and also causes alteration of serum parameters and various biomarkers indicating systemic damage. The purified extract of Bellamya bengalensis (PBB) exhibited dose-dependent significant anti-arthritic and antioxidant activities and restoration of biomarkers to near normal levels. Conclusion: This study demonstrated the therapeutic effect of Bellamya bengalensis Lamarck in FCA induced arthritic model. This might be mediated controlling the signaling pathways for the formation of reactive oxygen species followed by cellular damage.
Authors and Affiliations
A. Adhikari et al.
Keywords
Related Articles
- EP ID EP581520
- DOI 10.13040/IJPSR.0975-8232.10(6).3092-00
- Views 79
- Downloads 0
PREVALENCE OF COGNITIVE IMPAIRMENT IN METABOLIC SYNDROME PATIENTS IN URBAN INDIA
The association between metabolic syndrome and cognitive impairment is not well established. The aim of the present study was to estimate the prevalence of cognitive impairment in adults with metabolic syndrome (MetS). M...
SIMULTANEOUS ESTIMATION OF ATORVASTATIN AND CLOPIDOGREL BY SIMULTANEOUS EQUATION METHOD IN CAPSULE DOSAGE FORM
The current work is intended towards the development of a simple, rapid and precise UV-Visible spectrophotometric method for the simultaneous estimation of Atorvastatin (ATR) and Clopidogrel (CP) present in the marketed...
DISINFECTANTS, REGULATION AND REQUIREMENTS - GLOBAL OVERVIEW
Surface disinfectant is the multi-billion-dollar global industry with continuous growth opportunities linked to advancements in technology and innovations. However, innovations and new advancements do not always reach co...
AN IN-VITRO PHAGE THERAPY – IN OPPOSITION TO FOOD POISON ENGENDERED STAPHYLOCOCCUS AUREUS VIA PRECISE BACTERIOPHAGE FROM TIRUNELVELI DISTRICT, TAMIL NADU
Staphylococcus aureus, the facultative anaerobic and opportunistic Bacterium has been characterized as the pathogen with diversified molecular adaptability leading to the emergence of MDR. Advanced use of alternate antib...
ANTIFUNGAL ACTIVITIES OF PANGIUM EDULE REINW SEED EXTRACTS INHIBIT THE GROWTH OF ASPERGILLUS FLAVUS, PRODUCER OF AFLATOXINS, THROUGH THE IN-VITRO TEST
Aspergillus flavus is a famous fungus that produces aflatoxins. Aflatoxins are the most well known toxic and carcinogenic chemical prominent produced in nature. The fungus and aflatoxins are the main concern of the corn...