Therapeutic Efficacy of Intra-Articular Hyaluronic Acid in Osteoarthritis Knee
Journal Title: Journal of Bone and Joint Diseases - Year 2017, Vol 0, Issue 0
Abstract
Objective: To evaluate the effect of intra articular hyaluronic acid for patients with knee osteoarthritis by analysing data from trial of intra articular hyaluronic acid versus placebo. Material and method: This prospective study was conducted in department of orthopaedics, S.N. Medical College, Agra. Approval for study was taken by the local ethical committee. Objective was to evaluate the effect of intra articular hyaluronic acid for patients with knee osteoarthritis by analysing data from trial of intra articular hyaluronic acid versus placebo. Osteoarthritic knees of 112 patients (65 female and 47 male) with age of 40-80 years taken, patients were randomized to five weekly injections of intra articular hyaluronic acid or normal saline (control) and were observed for 36 weeks. The primary efficacy measures were resting pain, weight-bearing pain. VAS Score and WOMAC (Western Ontario and McMaster University Osteoarthritis Index) during study weeks 0–36. Results: The intra-articular injections produced a significant reduction in weight-bearing pain, resting pain, VAS Score and WOMAC scores after 12 weeks. Knee pain reduced and the function improved in most patients of hyaluronic acid group and these beneficial effects maintain till the last follow up. Adverse reactions were noted in 4 patients of Group1 and 3 patients of Group 2, out of which local reaction (swelling, redness, warmth, effusion, itching and Bruising) was common. Conclusion: Viscosupplementation with intra-articular hyaluronic acid is a reasonable treatment for patients with mild-to-moderate osteoarthritis of the knee who have ongoing pain or are unable to tolerate conservative treatment or joint replacement.
Authors and Affiliations
Chandra Prakash Pal, Ashwani Sadana, Amrit goyal, Ravi mehrotra, Pawan Kumar
Keywords
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