Therapeutic potential of adenosine analogues and conjugates.

Journal Title: Pharmacological Reports - Year 2011, Vol 63, Issue 3

Abstract

This review summarizes current knowledge of adenosine analogues and conjugates with promising therapeutic properties. Adenosine is a signaling molecule that triggers numerous physiological responses. It acts through the adenosine receptors (ARs), belonging to the family of G-protein-coupled receptors and widely distributed throughout the body. Moreover, adenosine is involved in key biochemical processes as a part of ATP, the universal energy currency. Thus, compounds that are analogues of adenosine and its conjugates have been extensively studied as potential therapeutics. Many inhibitors of ARs are in clinical trials as promising agents in treatment of inflammation, type 2 diabetes, arrhythmia and as vasodilators used in the myocardial perfusion imaging (MPI) stress test. Furthermore, adenosine analogues revealed high efficacy as enzyme inhibitors, tested for antitrypanosomal action and as bivalent igands and adenosine-oligoarginine conjugates as inhibitors of protein kinases.

Authors and Affiliations

Monika Samsel, Krystyna Dzierzbicka

Keywords

Related Articles

Influence of ABCB1 gene polymorphisms on the pharmacokinetics of azithromycin among healthy Chinese Han ethnic subjects.

The aim of this study was to evaluate the effects of ABCB1 gene polymorphisms on azithromycin pharmacokinetics in Chinese Han ethnic subjects. In total, 20 healthy volunteers with various ABCB1 genotypes (6 with 2677GG/3...

Antidepressant treatments-induced modifications of glutamatergic transmission in rat frontal cortex.

The effects of repeated administration of imipramine, citalopram, tianeptine and zinc hydroaspartate, lasting 7, 14 and 21 days, were studied ex vivo in rat frontal cortical slices prepared 48 h after the last dose of th...

Effects of thiopental and propofol on heart rate variability during fentanyl-based induction of general anesthesia.

Anesthetics depress the autonomic nervous system. The effects of thiopental and propofol on heart rate variability (HRV) during fentanyl-based induction of general anesthesia were studied in one hundred patients. We obse...

Blood platelet abnormalities and pharmacological modulation of platelet reactivity in patients with diabetes mellitus.

The overall picture of platelet abnormalities in diabetes mellitus (DM), including altered adhesion and aggregation, is hypersensitivity of diabetic platelets to agonists. "Primed" diabetic platelets respond more frequen...

Effect of acute and chronic treatment with QCF-3 (4-benzylpiperazin-1-yl) (quinoxalin-2-yl) methanone, a novel 5-HT(3) receptor antagonist, in animal models of depression.

The serotonin type 3 (5-HT(3)) receptor is unique among the seven recognized serotonin receptor "families". The existence serotonin type 3 receptor (5-HT(3)) in neuro-anatomical regions stimulated the research interest f...

Download PDF file
  • EP ID EP155506
  • DOI -
  • Views 102
  • Downloads 0

How To Cite

Monika Samsel, Krystyna Dzierzbicka (2011). Therapeutic potential of adenosine analogues and conjugates.. Pharmacological Reports, 63(3), 601-617. https://europub.co.uk/articles/-A-155506