Therapeutic potential of adenosine analogues and conjugates.

Journal Title: Pharmacological Reports - Year 2011, Vol 63, Issue 3

Abstract

This review summarizes current knowledge of adenosine analogues and conjugates with promising therapeutic properties. Adenosine is a signaling molecule that triggers numerous physiological responses. It acts through the adenosine receptors (ARs), belonging to the family of G-protein-coupled receptors and widely distributed throughout the body. Moreover, adenosine is involved in key biochemical processes as a part of ATP, the universal energy currency. Thus, compounds that are analogues of adenosine and its conjugates have been extensively studied as potential therapeutics. Many inhibitors of ARs are in clinical trials as promising agents in treatment of inflammation, type 2 diabetes, arrhythmia and as vasodilators used in the myocardial perfusion imaging (MPI) stress test. Furthermore, adenosine analogues revealed high efficacy as enzyme inhibitors, tested for antitrypanosomal action and as bivalent igands and adenosine-oligoarginine conjugates as inhibitors of protein kinases.

Authors and Affiliations

Monika Samsel, Krystyna Dzierzbicka

Keywords

Related Articles

Chronic imipramine treatment reduces inhibitory properties of group II mGlu receptors without affecting their density or affinity.

An increasing body of evidence indicates an important role of the glutamatergic system in the pathophysiology of depression. Not only ionotropic but also metabotropic glutamate receptors (mGlu receptors) have been sugges...

Anti-inflammatory and side effects of cyclooxygenase inhibitors.

Nonsteroidal anti-inflammatory drugs (NSAIDs) are the most commonly used drugs in inflammatory diseases, since they are effective in management of pain, fever, redness, edema arising as a consequence of inflammatory medi...

Effects of catecholamines on blood pressure in the long bone marrow cavity in rats with bisphosphonate-induced osteopetrosis.

Osteopetrosis is a congenital metabolic bone disease characterized by skeletal sclerosis resulting from defective osteoclast-mediated bone resorption. The disease may, inter alia, be caused by the administration of bisph...

Endothelin receptor antagonist CPU0213 suppresses ventricular fibrillation in L-thyroxin induced cardiomyopathy.

Arrhythmias correlate with disorders of either K(2+) channels in sarcolemma or calcium modulating system in sarcoplasmic reticulum which handles Ca(2+) intracellularly. We hypothesized that an activated endothelin (ET) s...

ESR techniques for the detection of nitric oxide in vivo as an index of endothelial function.

Plasma nitrite/nitrate levels reflect oxidation of formed nitric oxide (NO ) but are not indicative of endothelial nitric oxide synthase (eNOS) function due to interference by dietary nitrates and reactive oxygen species...

Download PDF file
  • EP ID EP155506
  • DOI -
  • Views 103
  • Downloads 0

How To Cite

Monika Samsel, Krystyna Dzierzbicka (2011). Therapeutic potential of adenosine analogues and conjugates.. Pharmacological Reports, 63(3), 601-617. https://europub.co.uk/articles/-A-155506