Thermogravimetric investigations of suppositories with diltiazem
Journal Title: Фармацевтичний журнал - Year 2015, Vol 3, Issue 3
Abstract
Diltiazem is one of the most widely used calcium antagonist in clinical practice. The results of its action are the lowering of myocardium oxygen need, improvement of the coronary blood flow and reducing of arterial pressure. Side effects of its oral and injection administration can be smoothed over by the transmucosal administration of diltiazem, in particular rectal with using of suitable dosage forms. The aim of this work is study of thermal treatment effects of suppository base with diltiazem over the temperature range of suppository manufacturing. On the base of carried out thermogravimetric investigations on the derivatograph Shimadzu DTG-60 (Japan) it was determined that thermal treatment of the suppository mass on the lipophylic factory fat base with 2% distilled monoglycerides over the temperature range of suppository manufacturing (70–80 ºС) doesn’t lead to destruction of its components. It was elicited a fact that developed medication is a mechanical mixture of the active substance and excipients because its ingredients don’t interact between each other.
Authors and Affiliations
K. R. Kuchina, V. V. Gladyshev, I. A. Biruk
Keywords
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