THYMOL ESTER OF GAMMA-AMINOBUTYRIC ACID: SYNTHESIS AND ANTICONVULSANT ACTIVITY
Journal Title: Вісник Одеського національного університету. Хімія - Year 2015, Vol 20, Issue 4
Abstract
Thymol ester of gamma-aminobutyric acid (GABA) − 2-isopropyl-5-methylphenyl 4-aminobutyrate hydrochloride − was synthesized via Steglich esterification and characterized by 1H NMR, IR and mass spectral studies. The anticonvulsant activity of obtained compound was estimated over a wide range of doses 5-80 mg/kg by determining the minimum effective doses of pentylenetetrazole inducing clonic-tonic convulsions and tonic extension. Present findings indicate that thymol ester of GABA is not a classical prodrug and possesses its own pharmacological activity. Prolonged antiseizure action of thymol derivative (20 mg/kg) was revealed at 24 hours after oral administration. Furthermore, orally co-administered gidazepam (1 mg/kg) and thymol ester of GABA (20 mg/kg) produce synergistic effect in seizures prevention.
Authors and Affiliations
M. V. Nesterkina, I. A. Kravchenko
Keywords
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- EP ID EP411633
- DOI 10.18524/2304-0947.2015.4(56).56695
- Views 64
- Downloads 0
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