Thyroid Dysfunction in Pregnancy and Preeclampsia
Journal Title: Scholars Journal of Applied Medical Sciences - Year 2014, Vol 2, Issue 6
Abstract
Pre -eclampsia is a leading cause of maternal & foetal morbidity & mortality worldwide. There is a state of hypothyroxinemia in normal pregnancy, it is more pronounced in preeclampsia. Moreover hypothyroidism has been listed as one of the causes of high blood pressure. Few studies have showed the effect on TSH levels exposing pre-eclamptic patients to the risk for low birth weight babies. Our study investigates the functioning of thyroid gland in normal pregnancy and in preeclampsia. Study was conducted on 30 diagnosed patients of preeclampsia and 30 age and parity matched normotensive pregnant subjects. Blood samples from both the groups were assayed by CLIA (chemiluminescence immunoassay) system for Thyroxine (T4), Tri-iodothyronine (T3) & Thyroid stimulating hormone (TSH). Comparison between both the groups was done by unpaired‘t’ test .There was no significant difference in the T4 & T3 levels in normal pregnancy and in pre-eclampsia. TSH levels in pre-eclampsia patients were increased significantly. The study shows significant increase in the TSH levels in pre-eclampsia than in normal pregnancy. The thyroid disorder is one of the predisposing causes for pre-eclampsia. Hence thyroid hormonal assay can be considered as a screening test for early diagnosis and treatment of pre-eclampsia to prevent further complications of it. Keywords: Preeclampsia, Thyroxine (T4), Tri-iodothyronine (T3), Thyroid stimulating hormone (TSH)
Authors and Affiliations
Manjunatha S, Basavraja GN, Ramesh S Patil
Keywords
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