Thyroid Lesions Classification Using Bethesda System with Histopathological Correlation and Calculating Each Category Malignancy Risk.
Journal Title: Indian Journal of Pathology: Research and Practice - Year 2018, Vol 7, Issue 8
Abstract
Introduction: Fine-needle aspiration is well established and the best test in the primary diagnosis of disorders of Thyroid with a high accuracy. A uniform reporting system for thyroid FNA will facilitate effective communication among all health professionals. Aims and Objectives: The aim of the study is to provide consistent diagnostic terminology by using new reporting system – Bethesda system. Cytopathology to histopathology correlation help us to calculate the malignancy risk rates of the different BSRTC categories at each individual institution. Material and Methods: The evaluation begins with demographic factors, physical examination, appropriate investigations, cytological, histopathological correlation and calculating malignancy risk for each category. 1,057 patients of all ages and sexes with clinical diagnosis of goitre in teritiary health care centre were studied. Results: Out of 1,057 patients, 931 were female and 126 were male patients. Fnac was done in all 1,057 cases and classified the lesions on FNAC using standard system of Bethesda. Out of 1,057 cases, 35 cases were diagnosed as Non Diagnostic/Unsatisfactory, 906 cases as Benign, 57 case as Atypia of undetermined significance/atypical follicular lesion of undetermined significance, 29 as follicular neoplasm/suspicious of follicular neoplasm/ Hurthle cell neoplasm/suspicious of Hurthle cell neoplasm, 11 as suspicious of malignancy and 19 as Malignancy. Out of 1,057 patients, 130 were undergone different modalities of surgical treatment. On histpathology examination out of 130 cases, 43 were Multinodular goitre, 06 were colloid goitre/Colloid cyst, 09 were Hashimotos thyroiditis, 21 were Adenomatoid Goitre, 21 were FollicularAdenoma, 1 was hurthle cell adenoma, 3 were Follicular Carcinoma, 2 were Hurthle cell neoplasm, 17 were Papillary Carcinoma, 3 were Follicular variant of Papillary carcinoma and 4 were Micropapillary carcinoma. Conclusion: Standard reporting system will help to reduce different diagnostic schema used by different institutions.
Authors and Affiliations
B. Shanti Damayanthi
Keywords
Related Articles
- EP ID EP526128
- DOI 10.21088/ijprp.2278.148X.7818.1
- Views 73
- Downloads 0
A Histopathological Study of Neoplastic and Non-Neoplastic Breast Lesions at a Rural Tertiary Care Centre in India
Although clinical and radiographic examination for breast lesions have come to play an important role in the assessment of the malignant potential of a lesion involving the breast, histopathology remains the gold standar...
Screening of Blood Donors for Transfusion Transmitted Infections: Is Zero Risk Blood Supply Possible?
Context: Blood transfusion service is a vital part of the National health service and there is no substitute for human blood and its components. Main objective of National blood policy is to provide safe, adequate quanti...
Study of HER-2 Gene Amplification by Chromogenic in-situ hybridization and HER-2 Protein Amplification by IHC in Breast Cancer using Manual Tissue Microarray Sections
Aim: Breast cancer is the most common cancer in women affecting one in eight in their lifetime [1]. HER-2 gene is amplified in approximately 20-40% of breast cancers [2], which correlates with aggressive disease and amen...
Immunohistochemical Correlation with Morphological Evolution of Urinary Bladder Tumors
Context: Urinary bladder diagnosis can be challenging and conventional markers used were cytokeratins. The new additions are GATA 3, uroplakin and S100P. This study helps to analyze immunohistochemical expression of pane...
P53 Staining Pattern in Benign, Premalignant and Malignant Oral Lesions
Introduction: Recent advance in the field of tumour suppressor genes and oncogenes have provided the tool for the study the genetic changes occurring at different stages of carcinogenesis including transition from premal...