Tissue Depth Study for a Fully Implantable, Remotely Powered and Programmable Wireless Neural Stimulator
Journal Title: International Journal of Nano Studies & Technology (IJNST) - Year 2016, Vol 0, Issue 1
Abstract
Miniature, remotely powered and programmable neural stimulators were implanted on the sciatic nerve in nine pig hind limbs. An external dipole antenna was used to transmit power and waveforms to the implant at 915 MHz. For each placement location, external power was swept until motor threshold was achieved. Thresholds were determined via visual observation of muscle twitches in the lower leg. The external antenna was placed at several different distances from the implant and the threshold power was recorded as a function of the tissue thickness overlying the implant. Verification of the current was measured by: 1) optical recording electrodes and 2) Random validation using wired recording electrodes. Both methods recorded the current required to reach motor threshold. Results from these tests confirmed that wireless neural stimulation could effectively excite motor nerves remotely in up to 12 cm of soft tissue of a mixed medium. Propagation losses for this verification also agreed with simulation models. These measurements verified that ample current densities could be achieved at significant tissue depths and therefore, a wireless neural stimulator can be potentially be utilized in existing neural stimulation therapeutic treatments.
Authors and Affiliations
Laura Tyler Perryman
Keywords
Related Articles
- EP ID EP201538
- DOI 10.19070/2167-8685-SI02001
- Views 86
- Downloads 0
Development and Evaluation of an Aqueous Polymeric Dispersion of Eudragit L 100-55 Using Emulsification Technology
Aqueous polymer dispersions (APD) are preferred on environmental and safety grounds. APD offer several advantages over polymers dissolved in organic solvents including lower spraying viscosities, higher solids loading, h...
Superparamagnetic Iron Oxide Nanoparticles (SPIONS): The King in The Cosmos of Multimodal Onco–Nanotheranostics.
The holistic religion of SPIONS in the era of modern medical oncology offers infinite, exhilarating possibilities in targeted hurling of tumours, thereby quenching the thirst of cancer researchers and retaining the gist...
Techniques Used For Development of Aqueous Polymeric Dispersion
Recent trends in pharmaceutical industry are development of coating methods which overcomes the various disadvantages associated with solvent based coatings. Water insoluble polymers have largely superseded the use of or...
Nanoscale Small Interfering RNA Delivery Systems For Personalized Cancer Therapy
Nanoparticles represent particularly attractive delivery systems for small interfering RNA (siRNA) and may provide the foundation for rational design and formulation of RNAi-triggering nanomedicines. siRNA can be deliver...
A Comparative Study on the Textile Effluent Decolourization by Using Synthesized Nano Particle and Procured Nano Particle
Semiconductor photocatalysis often leads to partial or complete mineralization of organic pollutants. Upon irradiation with UV/visible light, semiconductors catalyze redox reactions in presence of air/O2 and water. Here...