To Compare Intravenous Dexmedetomidine, Clonidine and Fentanyl in Attenuating the Haemodynamic Response to Laryngoscopy and Endotracheal Intubation
Journal Title: International Journal of Medical Science and Innovative Research (IJMSIR) - Year 2018, Vol 3, Issue 6
Abstract
Aims and objectives : To compare the efficacy of iv Dexmedetomidine 0.6μgkg-1, iv Clonidine 1μgkg-1 and iv Fentanyl 2μgkg-1 for attenuating increase in HR, SBP,DBP and MAP during laryngoscopy and intubation under general anaesthesia and to study their side effects. Material &Methods : Study was conducted in the Department of Anaesthesiology and Critical Care, Pt. B. D. Sharma, PGIMS, Rohtak in a prospective double-blind randomised manner. Hundred and fifty patients aged between 18 to 50 years belonging to ASA grade I ,II were randomly divided into three groups , each group consists of 50 patients .Basal HR , SBP, DBP ,MAP (B1) were recorded. Group I(Dexmedetomidine group) received iv Dexmedetomidine 0.6µgkg-1,group II (Clonidine group ) received iv Clonidine 1.0µgkg-1,group III (Fentanyl group ) received iv Fentanyl 2.0µgkg-1. Study parameters were recorded ten minutes before intubation (B2), just before (T0) intubation and 1 minute (T1) , 3 minutes (T3) , 5 minutes (T5) after intubation. Results: In our study, HR response to laryngoscopy and intubation was significantly attenuated by dexmedetomidine. However there was no attenuation with clonidine and fentanyl. SBP, DBP and MAP rise following intubation was completely obtunded by dexmedetomidine as compared to clonidine and fentanyl. Conclusion: Preoperative administration of a single dose of dexmedetomidine blunted the haemodynamic responses more than clonidine and fentanyl during laryngoscopy and intubation.
Authors and Affiliations
Dr Vineet Kumar
Keywords
Related Articles
- EP ID EP511952
- DOI -
- Views 102
- Downloads 0
The Incidence, severity, outcome and preventive measures of burn injuries in epileptic patients: An experience of burn unit in Govt. Medical College Srinagar.
Background: Burn injury among epileptic patients is very common and results in significant morbidity and mortality. Epileptics constitute a group of people who are vulnerable to injuries during seizures. The aim of this...
Correlation of Electrocardiography with Echocardiography of Left Ventricular Hypertrophy in Patients with Systemic Arterial Hypertension.
Left ventricular hypertrophy is a unvarying predictor of adverse CV hazards. Electrocardiography is one of most routinely used methods for diagnosing left ventricular hypertrophy due to low cost and easy availability. Ec...
Prediction of Cesarean delivery in Term Nulliparous Women after Induction of Labor at a Tertiary care teaching Hospitalof North India
Aim: To identify independent predictors of cesarean section in a term nulliparous women. Methods: A cohort study included of 300 nulliparous patients presenting in labour at term with singleton vertex fe...
Modification of Robson Classification for Caesarean Section Audit
Introduction With increased safety of operative deliveries the rate of caesarean section have been increasing steadily all over the world. Analysis of the caesarean section rate of a centre would allow insight into pre...
Role of Myofibroblast and Its Evaluation by Alpha Smooth Muscle Actin in Squamous Cell Carcinoma of Tongue and Buccal Mucosa In Relation To Lymph Node Metastasis
Background: Myofibroblasts are a relevant component in the stroma of oral cancer cells, however they are not present in all Oral Squamous Cell Carcinoma(OSCC) cases. These are involved in the contractile function during...