To Compare Intravenous Dexmedetomidine, Clonidine and Fentanyl in Attenuating the Haemodynamic Response to Laryngoscopy and Endotracheal Intubation
Journal Title: International Journal of Medical Science and Innovative Research (IJMSIR) - Year 2018, Vol 3, Issue 6
Abstract
Aims and objectives : To compare the efficacy of iv Dexmedetomidine 0.6μgkg-1, iv Clonidine 1μgkg-1 and iv Fentanyl 2μgkg-1 for attenuating increase in HR, SBP,DBP and MAP during laryngoscopy and intubation under general anaesthesia and to study their side effects. Material &Methods : Study was conducted in the Department of Anaesthesiology and Critical Care, Pt. B. D. Sharma, PGIMS, Rohtak in a prospective double-blind randomised manner. Hundred and fifty patients aged between 18 to 50 years belonging to ASA grade I ,II were randomly divided into three groups , each group consists of 50 patients .Basal HR , SBP, DBP ,MAP (B1) were recorded. Group I(Dexmedetomidine group) received iv Dexmedetomidine 0.6µgkg-1,group II (Clonidine group ) received iv Clonidine 1.0µgkg-1,group III (Fentanyl group ) received iv Fentanyl 2.0µgkg-1. Study parameters were recorded ten minutes before intubation (B2), just before (T0) intubation and 1 minute (T1) , 3 minutes (T3) , 5 minutes (T5) after intubation. Results: In our study, HR response to laryngoscopy and intubation was significantly attenuated by dexmedetomidine. However there was no attenuation with clonidine and fentanyl. SBP, DBP and MAP rise following intubation was completely obtunded by dexmedetomidine as compared to clonidine and fentanyl. Conclusion: Preoperative administration of a single dose of dexmedetomidine blunted the haemodynamic responses more than clonidine and fentanyl during laryngoscopy and intubation.
Authors and Affiliations
Dr Vineet Kumar
Keywords
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