To Compare the Effects of Dexmedetomidine and Midazolam for Conscious Sedation in Patients Undergoing Upper Gastrointestinal Endoscopic Procedures- an open labelled prospective study
Journal Title: Scholars Journal of Applied Medical Sciences - Year 2017, Vol 5, Issue 4
Abstract
Abstract: Our aim was to compare the hemodynamic parameters, sedation profile, duration of procedure and recovery profile of intravenous Dexmedetomidine and Midazolam in patients undergoing upper gastrointestinal endoscopic (UGIE) procedures. Hundred subjects posted for elective UGIE procedures were randomised into 2 groups. Both groups received fentanyl 1 mcg/kg IV at beginning of procedure. Group M received IV midazolam (0.04mg/kg) until Ramsay Sedation Scale (RSS) reached 3-4. Group D received Dexmedetomidine at loading dose of 1 mcg/kg over 10 minutes till RSS reached 3-4. The intraoperative hemodynamics was recorded. The time to achieve RSS 3-4 and Modified Aldrete Score( MAS) of 9-10 was assessed .The total duration of procedure and facial pain score(FPS) were compared during the procedure . We found that RSS of 3-4 was achieved earlier in group M (3.64 min) as compared to group D (9.92 min); (P<0.001). The total time taken for the procedure was higher in D group than group M (P <0.001). In our study, no patient had respiratory depression or hypoxemia during the procedure. No patient had coughing in group D while 16% of patients in group M had cough during the procedure which was significant (p=0.003) .Overall better recovery profile (MAS) was seen in group D (P<0.001). Dexmedetomidine seems to be promising agent for conscious sedation than Midazolam in UGIE procedures. Keywords:Dexmedetomidine, Midazolam, upper gastrointestinal endoscopic (UGIE) procedures, conscious sedation, Ramsay sedation score, recovery profile
Authors and Affiliations
Nidhi Jain, Jyotsna Bhargava, Anshu SS Kotia, Rajeev Lochan Tiwari
Keywords
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