To determine antibiotic susceptibility pattern along with Methicillin Resistance in the isolated Staphyloccus aureus – A study in Fathima Hospital
Journal Title: International Archives of Integrated Medicine - Year 2016, Vol 3, Issue 7
Abstract
Background: Over the last four decades Methicillin Resistant Staphylococcus aureus (MRSA) has spread throughout the world and has become highly endemic in many geographical areas. Materials and methods: Methicillin resistance was determined by 2 methods: Disk diffusion method using Oxacillin 1µg disk and MIC HiComb strips. Results: Out of 170 isolates 105 strains were Coagulase Positive and 65 strains Coagulase Negative Staphylococci. Most effective markers were Thermonuclease test and growth on high salt agar. 89 (84.76%) of the 105 isolates showed resistance to Penicillin, 54 (51.42%) to Amyoxyclav, 81 (77.14%) to Cefdinir, 61 (58.0%) to Cefepime, 86 (81.92%) to Gentamicin, 44 (41.9%) to Clindamycin, 40 (38.0%) to Amikacin, 82 (78.0%) to Erythromycin, 51 (48.57%) to Cotrimoxazole and 69 (65.71%) to Ofloxacin. Maximum resistance was seen for Penicillin and least to Amikacin. Oxacillin Disc diffusion method: Among 105 isolates 48 (45.7%) were susceptible to Oxacillin, 9 (8.57%) showed intermediate sensitivity and 48 (45.7%) were resistant to Oxacillin. MIC Determination by MIC HiComb strips: Among 105 isolates 59 (56.1%) showed MIC ≤ 2 µg indicating susceptible strains and 46 (43.8%) isolates showed MIC 4 > µg indicating Methicillin resistance. Conclusion: The antimicrobial resistance pattern in the present study gives serious reason for concern because majority of the strains are highly resistant to commonly available antibiotics. Surveillance studies should be carried out in every geographical area to detect the prevalence of MRSA strains and appropriate infection control measures should be performed. In conclusion, considering the increasing occurrence of MRSA infections, highly reliable, accurate and rapid testing for Methicillin Resistance is essential for both antibiotic therapy and infection control regimens.
Authors and Affiliations
Animireddy Kishore, G. Obulesu
Keywords
Related Articles
- EP ID EP487503
- DOI -
- Views 114
- Downloads 0
A study of post-partum persistence of glucose intolerance and its association with metabolic risk factors in gestational diabetes mellitus patients in urban South-Indian population
Background: Gestational diabetes mellitus, as a metabolic disorder affects 1%-28% of pregnancies. History of gestational diabetes is an important predictor of various metabolic disturbances later in life. This study was...
A clinical study of incidence, risk factor profile, and prognosis in cases of posterior circulation stroke
Background: The etiology of posterior circulation ischemia has been thought to be primarily due to local arterial atherosclerosis (large artery disease) and penetrating artery disease (lacunes). However, there is increas...
The role of prophylactic cefazolin in the prevention of infection after various types of abdominal wall hernia repair with mesh
Aim: This study aimed to evaluate the role of cefazolin in prevention of various infections after abdominal wall repair by mesh. Materials and methods: This is a prospective study consisted of 300 patients with various...
Study of chronic sinusitis to radiological and diagnostic nasal endoscopic examination findings
Introduction: Chronic sinusitis is a very common problem in ENT practice. Variations have an anatomic and surgical significance, each and every case should be individually studied in detail before surgery to maximize pat...
Non-invasive evaluation of renal arterial blood flow in alcoholic cirrhosis of liver
Introduction: Studies of renal perfusion when kidney function tests are still normal could be useful in understanding the pathophysiology of functional kidney impairment in cirrhosis. Kidney functional failure in cirrhos...